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Ligands of CR2 do not interfere with C3 fragment fixation or enhanced NK sensitivity of Raji cells treated with human serum.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology.
1989 (English)In: Immunology Letters, ISSN 0165-2478, E-ISSN 1879-0542, Vol. 21, no 4, 303-306 p.Article in journal (Refereed) Published
Abstract [en]

Raji cells activate the alternative complement pathway (ACP) and fix C3 fragments when incubated in human serum (HS). Earlier experiments have shown that CR2 molecules are involved in this phenomenon and the opsonized cells have elevated sensitivity to the lytic effect of CR3-bearing NK cells. We show here that Raji cells treated with CR2 site-specific ligands, (C3d, OKB-7 and HB-5 mAbs, and a synthetic peptide which binds to CR2) generated and bound C3 fragments after exposure to HS. The elevated lytic sensitivity of HS-treated cells was not altered by the presence of the various CR2 ligands. Thus, the membrane-bound C3 fragments are not fixed at the C3dg receptor binding site.

Place, publisher, year, edition, pages
1989. Vol. 21, no 4, 303-306 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-265393PubMedID: 2527817OAI: oai:DiVA.org:uu-265393DiVA: diva2:865440
Available from: 2015-10-28 Created: 2015-10-28 Last updated: 2015-10-28

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