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Defective Fc receptor-mediated clearance in patients with primary biliary cirrhosis.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology.
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1991 (English)In: Gastroenterology, ISSN 0016-5085, E-ISSN 1528-0012, Vol. 101, no 4, 1076-1082 p.Article in journal (Refereed) Published
Abstract [en]

Fc receptor-mediated clearance of immunoglobulin G-coated autologous erythrocytes was studied in patients with primary biliary cirrhosis (n = 14), alcoholic liver cirrhosis (n = 5) and healthy reference individuals (n = 14). The mean half-life of the sensitized erythrocytes was significantly prolonged in patients with primary biliary cirrhosis (85 +/- 25 minutes; P less than 0.001) compared with the corresponding value in patients with alcoholic cirrhosis (16 +/- 2 minutes) and healthy reference individuals (20 +/- 5 minutes), respectively. No correlation between clearance rate and age, liver histopathology, or serum levels of bilirubin, aminotransferases, immunoglobulin G, immunoglobulin A, and Clq binding or C3-containing immune complexes was found. The results presented here indicate a profound disturbance of Fc receptor-mediated immune clearance function in patients with primary biliary cirrhosis.

Place, publisher, year, edition, pages
1991. Vol. 101, no 4, 1076-1082 p.
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Medical and Health Sciences
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URN: urn:nbn:se:uu:diva-265453PubMedID: 1889700OAI: oai:DiVA.org:uu-265453DiVA: diva2:865714
Available from: 2015-10-29 Created: 2015-10-29 Last updated: 2017-12-01

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