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Complement activation by polymethyl methacrylate minimized by end-point heparin attachment.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology.
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1993 (English)In: Biomaterials, ISSN 0142-9612, E-ISSN 1878-5905, Vol. 14, no 3, 189-192 p.Article in journal (Refereed) Published
Abstract [en]

After intraocular lens implantation, despite good clinical results, many cataract patients develop a chronic uveitis, caused by an inflammatory response to the implant. One way to improve the biocompatibility of the intraocular lens is to modify the surface by end-point heparin attachment. This study shows that complement activation caused by poly(methyl methacrylate) can be diminished by end-point heparin attachment, as demonstrated by a significant reduction in the generation of C3a and fluid phase terminal complement complexes. It suggests that assessment of complement activation is a good indicator of the biocompatibility of intraocular lenses.

Place, publisher, year, edition, pages
1993. Vol. 14, no 3, 189-192 p.
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Medical and Health Sciences
URN: urn:nbn:se:uu:diva-265473PubMedID: 8476991OAI: oai:DiVA.org:uu-265473DiVA: diva2:865789
Available from: 2015-10-29 Created: 2015-10-29 Last updated: 2015-10-29

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