uu.seUppsala University Publications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Sick building syndrome (SBS) among office workers in a Malaysian university - Associations with atopy, fractional exhaled nitric oxide (FeNO) and the office environment
Univ Putra Malaysia, Fac Med & Hlth Sci, Dept Environm & Occupat Hlth, Upm Serdang 43400, Selangor, Malaysia..
Univ Putra Malaysia, Fac Med & Hlth Sci, Dept Environm & Occupat Hlth, Upm Serdang 43400, Selangor, Malaysia..
Univ Putra Malaysia, Fac Med & Hlth Sci, Dept Community Hlth, Upm Serdang 43400, Selangor, Malaysia..
Univ Putra Malaysia, Fac Med & Hlth Sci, Dept Med Microbiol & Parasitol, Upm Serdang 43400, Selangor, Malaysia..
Show others and affiliations
2015 (English)In: Science of the Total Environment, ISSN 0048-9697, E-ISSN 1879-1026, Vol. 536, 353-361 p.Article in journal (Refereed) Published
Abstract [en]

There are few studies on sick building syndrome (SBS) including clinical measurements for atopy and fractional exhaled nitric oxide (FeNO). Our aim was to study associations between SBS symptoms, selected personal factors, office characteristics and indoor office exposures among office workers from a university in Malaysia. Health data were collected by a questionnaire (n = 695), skin prick test (SPT) (n = 463) and FeNO test (n = 460). Office settled dust was vacuumed and analyzed for endotoxin, (1,3)-beta-glucan and house dust mites (HDM) allergens group 1 namely Dermatophagoides pteronyssinus (Der p 1) and Dermatophagoides farinae (Der f 1). Office indoor temperature, relative air humidity (RH), carbon monoxide (CO) and carbon dioxide (CO2) were measured by a direct reading instrument. Associations were studied by two-levelsmultiple logistic regression with mutual adjustment and stratified analysis. The prevalence of weekly dermal, mucosal and general symptoms was 11.9%, 16.0% and 23.0% respectively. A combination of SPT positivity (allergy to HDM or cat) and high FeNO level (>= 25 ppb) was associated with dermal (p = 0.002), mucosal (p <0.001) and general symptoms (p = 0.05). Der f1 level in dust was associated with dermal (p < 0.001), mucosal (p < 0.001) and general (p = 0.02) symptoms. Among those with allergy to D. farinae, associations were found between Der f 1 levels in dust and dermal (p = 0.003), mucosal (p = 0.001) and general symptoms (p = 0.007). Office-related symptoms were associated with Der f 1 levels in dust (p = 0.02), low relative air humidity (p = 0.04) and high office temperature (p = 0.05). In conclusion, a combination of allergy to cat or HDM and high FeNO is a risk factor for SBS symptoms. Der f 1 allergen in dust can be a risk factor for SBS in the office environment, particularly among those sensitized to Der f 1 allergen.

Place, publisher, year, edition, pages
2015. Vol. 536, 353-361 p.
Keyword [en]
Sick building syndrome, Allergy, House dust mites, Fractional exhaled nitric oxide, Office environment, Malaysia
National Category
Environmental Health and Occupational Health
Identifiers
URN: urn:nbn:se:uu:diva-264593DOI: 10.1016/j.scitotenv.2015.06.137ISI: 000361189800039PubMedID: 26225741OAI: oai:DiVA.org:uu-264593DiVA: diva2:866081
Funder
Swedish Research Council, 2013-6762
Available from: 2015-10-30 Created: 2015-10-15 Last updated: 2017-12-01Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Authority records BETA

Norbäck, Dan

Search in DiVA

By author/editor
Norbäck, Dan
By organisation
Occupational and Environmental Medicine
In the same journal
Science of the Total Environment
Environmental Health and Occupational Health

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 291 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf