uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Prostasomes: Their Characterisation: Implications for Human Reproduction
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Biochemial structure and function.
2015 (English)In: MALE ROLE IN PREGNANCY LOSS AND EMBRYO IMPLANTATION FAILURE, Springer, 2015, 191-209 p.Chapter in book (Refereed)
Abstract [en]

The prostate is a principal accessory genital gland that is vital for normal fertility. Epithelial cells lining the prostate acini release in a defined fashion (exocytosis) organellar nanosized structures named prostasomes. They are involved in the protection of sperm cells against immune response in the female reproductive tract by modulating the complement system and by inhibiting monocyte and neutrophil phagocytosis and lymphocyte proliferation. The immunomodulatory function most probably involves small non-coding RNAs present in prostasomes. Prostasomes have also been proposed to regulate the timing of sperm cell capacitation and induction of the acrosome reaction, since they are rich in various transferable bioactive molecules (e.g. receptors and enzymes) that promote the fertilising ability of sperm cells. Antigenicity of sperm cells has been well documented and implicated in involuntary immunological infertility of human couples, and antisperm antibodies (ASA) occur in several body fluids. The propensity of sperm cells to carry attached prostasomes suggests that they are a new category of sperm antigens. Circulating human ASA recognise prostasomes, and among 12 identified prostasomal antigens, prolactin-inducible protein (95 %) and clusterin (85 %) were immunodominant at the expense of the other 10 that were sporadically occurring.

Place, publisher, year, edition, pages
Springer, 2015. 191-209 p.
, Advances in Experimental Medicine and Biology, ISSN 0065-2598 ; 868
Keyword [en]
Prostasomes, Non-coding RNA, Seminal fluid, Spermatozoa, Antioxidants, Immunosuppression
National Category
Obstetrics, Gynecology and Reproductive Medicine
URN: urn:nbn:se:uu:diva-265648DOI: 10.1007/978-3-319-18881-2_9ISI: 000361813200010PubMedID: 26178851ISBN: 978-3-319-18881-2ISBN: 978-3-319-18880-5OAI: oai:DiVA.org:uu-265648DiVA: diva2:866417
Available from: 2015-11-02 Created: 2015-11-02 Last updated: 2015-11-05Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Ronquist, Gunnar
By organisation
Biochemial structure and function
Obstetrics, Gynecology and Reproductive Medicine

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 127 hits
ReferencesLink to record
Permanent link

Direct link