Prostasomes: Their Characterisation: Implications for Human Reproduction
2015 (English)In: MALE ROLE IN PREGNANCY LOSS AND EMBRYO IMPLANTATION FAILURE, Springer, 2015, 191-209 p.Chapter in book (Refereed)
The prostate is a principal accessory genital gland that is vital for normal fertility. Epithelial cells lining the prostate acini release in a defined fashion (exocytosis) organellar nanosized structures named prostasomes. They are involved in the protection of sperm cells against immune response in the female reproductive tract by modulating the complement system and by inhibiting monocyte and neutrophil phagocytosis and lymphocyte proliferation. The immunomodulatory function most probably involves small non-coding RNAs present in prostasomes. Prostasomes have also been proposed to regulate the timing of sperm cell capacitation and induction of the acrosome reaction, since they are rich in various transferable bioactive molecules (e.g. receptors and enzymes) that promote the fertilising ability of sperm cells. Antigenicity of sperm cells has been well documented and implicated in involuntary immunological infertility of human couples, and antisperm antibodies (ASA) occur in several body fluids. The propensity of sperm cells to carry attached prostasomes suggests that they are a new category of sperm antigens. Circulating human ASA recognise prostasomes, and among 12 identified prostasomal antigens, prolactin-inducible protein (95 %) and clusterin (85 %) were immunodominant at the expense of the other 10 that were sporadically occurring.
Place, publisher, year, edition, pages
Springer, 2015. 191-209 p.
, Advances in Experimental Medicine and Biology, ISSN 0065-2598 ; 868
Prostasomes, Non-coding RNA, Seminal fluid, Spermatozoa, Antioxidants, Immunosuppression
Obstetrics, Gynecology and Reproductive Medicine
IdentifiersURN: urn:nbn:se:uu:diva-265648DOI: 10.1007/978-3-319-18881-2_9ISI: 000361813200010PubMedID: 26178851ISBN: 978-3-319-18881-2ISBN: 978-3-319-18880-5OAI: oai:DiVA.org:uu-265648DiVA: diva2:866417