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Microtubule-associated proteins in adult human sensory organs
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences. (Oto-Rhino-Laryngology, Head & Neck Surgery)
1995 (English)In: Journal for Oto-Rhino-Laryngology, ISSN 0301-1569, Vol. 57, no 2, 78-81 p.Article in journal (Refereed) Published
Abstract [en]

The distribution of microtubule-associated proteins MAP-1 and MAP-2 was analysed with immunomorphological techniques in the serially sectioned adult human membranous labyrinth. In the organ of Corti, monoclonal antibodies to MAP-1 did not stain. Positivity for MAP-2 occurred in the entire outer hair cell cytoplasm, in the inner hair cells (?), in the nerve fibres and in the cytoplasm of epithelial cells of the spiral prominence. In addition, staining for MAP-2 was identified in many (but not all) cells or Reissner's membrane. Immunofluorescence for MAP-1 occurred in the supporting cells of the cristae and maculae interpreted to be localized in the apical region adjacent to the sensory cells. Thus, the distribution of MAP-1 and MAP-2 in the adult human membranous labyrinth was the same as described for several animal species with regard to the cochlea. In contrast to such a pattern, both MAP-1 and MAP-2 were identified in the human vestibular organs, thus identifying a subpopulation of centrally located nerve calyces and possibly also the apical portion of vestibular hair cells.

Place, publisher, year, edition, pages
1995. Vol. 57, no 2, 78-81 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-58737PubMedID: 7731660OAI: oai:DiVA.org:uu-58737DiVA: diva2:86646
Available from: 2008-10-17 Created: 2008-10-17 Last updated: 2010-02-24Bibliographically approved

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