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More signs of neurotoxicity of surfactants and flame retardants - Neonatal PFOS and PBDE 99 cause transcriptional alterations in cholinergic genes in the mouse CNS
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Organismal Biology, Environmental toxicology.
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Organismal Biology, Environmental toxicology.
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Organismal Biology, Environmental toxicology.
2015 (English)In: Environmental Toxicology and Pharmacology, ISSN 1382-6689, E-ISSN 1872-7077, Vol. 40, no 2, 409-416 p.Article in journal (Refereed) Published
Abstract [en]

Maternally and lactionally transferred persistent organic pollutants may interfere with CNS development. Here, 10-day-old male mice were exposed to single oral doses of PFOS (perflourooctanosulphonate) or PBDE 99 (2,2',4,4',5-penta-bromodiphenyl ether), and examined for changes in cholinergic gene transcription in the CNS 24 h and 7 weeks later. 24 h after exposure qPCR analyses revealed decreased transcription of nAChR-beta 2 and AChE in cortex, and increased mAChR-5 in hippocampus of PFOS treated mice. Neonatal PFOS treatment altered spontaneous behaviour at 2 months of age but did not affect gene transcription in adults. At 2 months of age neonatally PBDE 99 treated mice had altered spontaneous behaviour, and cortical transcription of AChE, nAChR-alpha 4, nAChR-beta 2 and mAChR-5 were elevated. Our results indicate that PFOS and PBDE 99 affects the developing central cholinergic system by altering gene transcription in cortex and hippocampus, which may in part account for mechanisms causing changes in spontaneous behaviour.

Place, publisher, year, edition, pages
2015. Vol. 40, no 2, 409-416 p.
Keyword [en]
Brominated flame retardants, Perflourinated chemical repellants, Developmental neurotoxicology, Cholinergic system, Brain growth spurt
National Category
Biological Sciences
Identifiers
URN: urn:nbn:se:uu:diva-265589DOI: 10.1016/j.etap.2015.06.014ISI: 000362619100010PubMedID: 26254212OAI: oai:DiVA.org:uu-265589DiVA: diva2:866504
Available from: 2015-11-03 Created: 2015-11-02 Last updated: 2017-12-01Bibliographically approved

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Hallgren, StefanFredriksson, AndersViberg, Henrik

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