Molecular organization and fine structure of the human tectorial membrane: is it replenished?
2015 (English)In: Cell and Tissue Research, ISSN 0302-766X, E-ISSN 1432-0878, Vol. 362, no 3, 513-527 p.Article in journal (Refereed) Published
Auditory sensitivity and frequency resolution depend on the physical properties of the basilar membrane in combination with outer hair cell-based amplification in the cochlea. The physiological role of the tectorial membrane (TM) in hair cell transduction has been controversial for decades. New insights into the TM structure and function have been gained from studies of targeted gene disruption. Several missense mutations in genes regulating the human TM structure have been described with phenotypic expressions. Here, we portray the remarkable gradient structure and molecular organization of the human TM. Ultrastructural analysis and confocal immunohistochemistry were performed in freshly fixed human cochleae obtained during surgery. Based on these findings and recent literature, we discuss the role of human TMs in hair cell activation. Moreover, the outcome proposes that the α-tectorin-positive amorphous layer of the human TM is replenished and partly undergoes regeneration during life.
Place, publisher, year, edition, pages
2015. Vol. 362, no 3, 513-527 p.
Tectorial membrane; Human; Electron microscopy; alpha-tectorin
Medical and Health Sciences Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)
IdentifiersURN: urn:nbn:se:uu:diva-265776DOI: 10.1007/s00441-015-2225-5ISI: 000366322300004PubMedID: 26085343OAI: oai:DiVA.org:uu-265776DiVA: diva2:866540
Corrections in Cell and Tissue Research, December 2015, Volume 362, Issue 3, pp 689-6902015-11-032015-11-032016-02-23Bibliographically approved