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Cytoskeletal proteins in human hair cells
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences. (Oto-Rhino-Laryngology, Head & Neck Surgery)
1995 (English)In: Acta oto-laryngologica. Supplementum, ISSN 0365-5237, Vol. 519, 8-12 p.Article in journal (Refereed) Published
Abstract [en]

Human cochlear and vestibular hair cells (HCs) were analysed for the three major cytoskeletal types of structures: microfilaments, microtubules, and intermediate filaments and several of their associated proteins. Specific immunomorphological features were identified: the apical surface, the infracuticular rod of F-actin, the cytoplasm and the HC bases and their interactions with adjacent supporting cells. There is morphological evidence for at least three functionally interacting units: the OHC as a cytoskeletal string interacting with the Deiter's cell, being a part of the rigid pancellular protein shell of the organ of Corti; compartmentalization of HCs (surrounded by rigid intermediate filament proteins in the supporting cells); and a calcium-guided short-loop feed-back control of type I HCs. The cytoskeletal composition of all four types of human HCs and their adjacent structures is similar to, although not identical with, corresponding compositions in other mammalian species.

Place, publisher, year, edition, pages
1995. Vol. 519, 8-12 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-58749PubMedID: 7610898OAI: oai:DiVA.org:uu-58749DiVA: diva2:86658
Available from: 2008-10-17 Created: 2008-10-17 Last updated: 2010-02-24Bibliographically approved

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