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Emerging Viruses in the Republic of Suriname: Retrospective and Prospective Study into Chikungunya Circulation and Suspicion of Human Hantavirus Infections, 2008-2012 and 2014
Erasmus MC, Virosci Dept, NL-3000 CA Rotterdam, Netherlands..
Erasmus MC, Virosci Dept, NL-3000 CA Rotterdam, Netherlands..
Erasmus MC, Virosci Dept, NL-3000 CA Rotterdam, Netherlands.;Univ Indonesia, Fac Med, Jakarta, Indonesia..
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology. Publ Hlth Agcy Sweden, Solna, Sweden..
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2015 (English)In: Vector Borne and Zoonotic Diseases, ISSN 1530-3667, E-ISSN 1557-7759, Vol. 15, no 10, 611-618 p.Article in journal (Refereed) Published
Abstract [en]

Introduction: Suriname is a country on the northeastern Atlantic coast of South America. It is unique in the sense that different ethnic cultures live together within the country, resulting in high levels of transport of both humans and products between the Asian, African, and European continents as well as the Caribbean. Travel is only one of the many factors present in Suriname contributing to the risk for the emergence or introduction of any infectious disease. Recently, circulation of both chikungunya virus (CHIKV) and hantavirus was reported in areas neighboring Suriname. Here we report a retrospective and prospective study into chikungunya and hantavirus circulation. Methods: A chikungunya and hantavirus retrospective serological study was conducted on samples submitted for dengue, leptospirosis, and/or influenza virus diagnostics between 2008 and 2012 to the Bureau of Public Health in Suriname. This was followed by a prospective CHIKV serological and molecular surveillance study until the detection of the first autochthonous CHIKV cases in Suriname in May and June of 2014. Results: None of the tested samples showed the presence of CHIKV antibodies in the retrospective serological study. Prospective testing of CHIKV-suspected patients resulted in the detection of the first autochthonous CHIKV cases in Suriname in May, 2015. In one sample, we were able to isolate and sequence the virus. Retrospective testing for the presence of hantavirus antibodies showed a relative high response in both pan-hantavirus enzyme-linked immunosorbent assay (ELISA) and immunofluorescence assay (IFA). However, neutralization tests did not yield any evidence for infection with either Seoul or Andes hantavirus. Conclusion: Here we report the presence of CHIKV in the republic of Suriname and the first serological indication of hantavirus infections in symptomatic patients.

Place, publisher, year, edition, pages
2015. Vol. 15, no 10, 611-618 p.
Keyword [en]
Chikungunya, Hantavirus, Hemorrhagic fever, Emerging infectious diseases, Suriname
National Category
Biochemistry and Molecular Biology Public Health, Global Health, Social Medicine and Epidemiology
Identifiers
URN: urn:nbn:se:uu:diva-265700DOI: 10.1089/vbz.2015.1798ISI: 000362098000006PubMedID: 26393384OAI: oai:DiVA.org:uu-265700DiVA: diva2:866595
Available from: 2015-11-03 Created: 2015-11-02 Last updated: 2017-12-01Bibliographically approved

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Lundkvist, Åke

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