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Cell Surface Engineering for Regulation of Immune Reactions in Cell Therapy
Univ Tokyo, Dept Bioengn, Bunkyo Ku, Tokyo 1138656, Japan..
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Clinical Immunology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Clinical Immunology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Clinical Immunology.
2015 (English)In: IMMUNE RESPONSES TO BIOSURFACES: MECHANISMS AND THERAPEUTIC INTERVENTIONS, 2015, 189-209 p.Conference paper, Published paper (Refereed)
Abstract [en]

Transplantation of the pancreatic islets of Langerhans (islets) is a promising cell therapy for treating insulin-dependent type 1 diabetes mellitus. Islet transplantation is a minimally-invasive technique involving relatively simple surgery. However, after intraportal transplantation, the transplanted islets are attacked by the recipient's immune system, because they activate a number of systems, including coagulation, complement response, inflammation, immune rejection, and recurrence of autoimmune disease. We have developed a surface modification and microencapsulation technique that protects cells and islets with biomaterials and bioactive substances, which may be useful in clinical settings. This approach employs amphiphilic polymers, which can interact with lipid bilayer membranes, without increasing cell volume. Molecules attached to these polymers can protect transplanted cells and islets from attack by the host immune system. We expect that this surface modification technique will improve graft survival in clinical islet transplantation.

Place, publisher, year, edition, pages
2015. 189-209 p.
Series
Advances in Experimental Medicine and Biology, ISSN 0065-2598 ; 865
Keyword [en]
Surface modification, Poly(ethylene glycol) (PEG), PEG-lipid, Islet transplantation, Instant blood-mediated inflammatory reaction (IBMIR), Diabetes, Biomaterials, Bioartificial pancreas, Microencapsulation
National Category
Immunology in the medical area
Identifiers
URN: urn:nbn:se:uu:diva-265644DOI: 10.1007/978-3-319-18603-0_12ISI: 000361838300013PubMedID: 26306451ISBN: 978-3-319-18603-0 (print)ISBN: 978-3-319-18602-3 (print)OAI: oai:DiVA.org:uu-265644DiVA: diva2:866642
Conference
1st International Conference on Immune Response to Biosurfaces, SEP 27-OCT 02, 2014, Chania, GREECE
Available from: 2015-11-03 Created: 2015-11-02 Last updated: 2015-11-05Bibliographically approved

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Asif, SanaEkdahl, Kristina N.Nilsson, Bo

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