Thromboinflammation in Therapeutic Medicine
2015 (English)In: IMMUNE RESPONSES TO BIOSURFACES: MECHANISMS AND THERAPEUTIC INTERVENTIONS, 2015, 3-17 p.Conference paper (Refereed)
Thromboinflammation is primarily triggered by the humoral innate immune system, which mainly consists of the cascade systems of the blood, i.e., the complement, contact/coagulation and fibrinolytic systems. Activation of these systems subsequently induces activation of endothelial cells, leukocytes and platelets, finally resulting in thrombotic and inflammatory reactions. Such reactions are triggered by a number of medical procedures, e.g., treatment with biomaterials or drug delivery devices as well as in transplantation with cells, cell clusters or whole vascularized organs. Here, we (1) describe basic mechanisms for thromboinflammation; (2) review thromboinflammatory reactions in therapeutic medicine; and (3) discuss emerging strategies to dampen thromboinflammation.
Place, publisher, year, edition, pages
2015. 3-17 p.
, Advances in Experimental Medicine and Biology, ISSN 0065-2598 ; 865
Coagulation, Complement, Extracorporeal treatment, Platelets, Therapeutic medicine, Thromboinflammation
Immunology in the medical area
IdentifiersURN: urn:nbn:se:uu:diva-265642DOI: 10.1007/978-3-319-18603-0_1ISI: 000361838300002PubMedID: 26306440ISBN: 978-3-319-18603-0ISBN: 978-3-319-18602-3OAI: oai:DiVA.org:uu-265642DiVA: diva2:866651
1st International Conference on Immune Response to Biosurfaces, SEP 27-OCT 02, 2014, Chania, GREECE
FunderSwedish Research Council, 2013-65X-05647-34-4EU, FP7, Seventh Framework Programme, 602699AFA Insurance