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Thromboinflammation in Therapeutic Medicine
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Clinical Immunology.
Univ Tokyo, Dept Bioengn, Bunkyo Ku, Tokyo 1138656, Japan..
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Clinical Immunology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Clinical Immunology.
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2015 (English)In: IMMUNE RESPONSES TO BIOSURFACES: MECHANISMS AND THERAPEUTIC INTERVENTIONS, 2015, 3-17 p.Conference paper, Published paper (Refereed)
Abstract [en]

Thromboinflammation is primarily triggered by the humoral innate immune system, which mainly consists of the cascade systems of the blood, i.e., the complement, contact/coagulation and fibrinolytic systems. Activation of these systems subsequently induces activation of endothelial cells, leukocytes and platelets, finally resulting in thrombotic and inflammatory reactions. Such reactions are triggered by a number of medical procedures, e.g., treatment with biomaterials or drug delivery devices as well as in transplantation with cells, cell clusters or whole vascularized organs. Here, we (1) describe basic mechanisms for thromboinflammation; (2) review thromboinflammatory reactions in therapeutic medicine; and (3) discuss emerging strategies to dampen thromboinflammation.

Place, publisher, year, edition, pages
2015. 3-17 p.
Series
Advances in Experimental Medicine and Biology, ISSN 0065-2598 ; 865
Keyword [en]
Coagulation, Complement, Extracorporeal treatment, Platelets, Therapeutic medicine, Thromboinflammation
National Category
Immunology in the medical area
Identifiers
URN: urn:nbn:se:uu:diva-265642DOI: 10.1007/978-3-319-18603-0_1ISI: 000361838300002PubMedID: 26306440ISBN: 978-3-319-18603-0 (print)ISBN: 978-3-319-18602-3 (print)OAI: oai:DiVA.org:uu-265642DiVA: diva2:866651
Conference
1st International Conference on Immune Response to Biosurfaces, SEP 27-OCT 02, 2014, Chania, GREECE
Funder
Swedish Research Council, 2013-65X-05647-34-4EU, FP7, Seventh Framework Programme, 602699AFA Insurance
Available from: 2015-11-03 Created: 2015-11-02 Last updated: 2015-11-05Bibliographically approved

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Nilsson, Kristina EkdahlAsif, SanaMagnusson, Peetra U.Nilsson, Bo

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