uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Chimerism analysis in clinical practice and its relevance for the detection of graft rejection and malignant relapse in pediatric hematopoietic stem cell transplant patients
Univ Gothenburg, Inst Clin Sci, Dept Pediat, Gothenburg, Sweden..
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Pediatrics.
Skane Univ Hosp, Dept Pediat, Sect Pediat Oncol Hematol, Lund, Sweden..
Karolinska Univ Hosp, Astrid Lindgren Childrens Hosp, Karolinska Inst, Dept Clin Sci Intervent & Technol, Stockholm, Sweden..
2015 (English)In: Pediatric Transplantation, ISSN 1397-3142, E-ISSN 1399-3046, Vol. 19, no 7, 758-766 p.Article in journal (Refereed) Published
Abstract [en]

Chimerism and clinical outcome data from 244 hematopoietic stem cell transplants in 218 children were retrospectively analyzed to assess their relevance for the detection of graft rejection and malignant relapse. Patients transplanted for a non-malignant disease had significantly higher proportions of residual recipient T cells in peripheral blood at one, three, and sixmonths compared with patients transplanted for malignant disease. Recipient T-cell levels were below 50% at onemonth after transplantation in most patients (129 of 152 transplants). Graft rejection occurred more frequently in the group of patients with high levels of recipient cells at onemonth (10 graft rejections in the 23 patients with recipient T cells >50% at onemonth as compared to seven graft rejections occurred in 129 patients with recipient T cells <50% (p<0.001). Multilineage chimerism data in 87 children with leukemia at one, three, and sixmonths after transplantation were not correlated with subsequent relapse of malignant disease. In conclusion, early analysis of lineage-specific chimerism in peripheral blood can be used to identify patients who are at high risk of graft rejection. However, the efficacy of early chimerism analysis for predicting leukemia relapse was limited.

Place, publisher, year, edition, pages
2015. Vol. 19, no 7, 758-766 p.
Keyword [en]
chimerism analysis, stem cell transplantation, pediatric patients
National Category
URN: urn:nbn:se:uu:diva-265805DOI: 10.1111/petr.12580ISI: 000362580100022PubMedID: 26290161OAI: oai:DiVA.org:uu-265805DiVA: diva2:866709
Swedish Childhood Cancer Foundation
Available from: 2015-11-03 Created: 2015-11-03 Last updated: 2015-11-03Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Arvidson, Johan
By organisation
In the same journal
Pediatric Transplantation

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 207 hits
ReferencesLink to record
Permanent link

Direct link