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Pneumococcal toxins reversibly affect cochlear electrophysiology
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences. (Oto-Rhino-Laryngology, Head & Neck Surgery)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine.
1998 (English)In: Oto-Rhino-Laryngologia Nova, ISSN 1014-8221, Vol. 8, no 2, 59-65 p.Article in journal (Refereed) Published
Abstract [en]

Objectives:Streptococcus pneumoniae (pneumococcus) produces various toxic proteins such as pneumolysin, autolysin, neuraminidase, hyaluronidase and pneumococcal surface protein A. To evaluate effects on the sensorineural component of hearing of such an infection in the middle ear a sterile suspension of pneumococcus containing all these toxins was instilled into the round window niche. Material and Methods: Inner ear function was evaluated by a frequency-specific auditory brainstem response (ABR) technique using the rat as experimental animal. Both ABR threshold curves and intensity-latency (I-L) curves were investigated. Results: The electrophysiological effects of pneumococcal toxin on the middle and the inner ear were moderate. Sensorineural hearing loss appeared from 1 day after instillation especially at high frequencies (31.5-20 kHz) and gradually extended into the frequencies 16, 14 and 12 kHz. The threshold impairment was reversible and improved within 2 weeks after exposure. The mean threshold change ranged from 5 to 10 dB at high frequencies. Conclusions: Our experimental results are compatible with previously reported clinical findings. The I-L curve investigation was useful to distinguish the changes due to conductive or sensorineural or mixed type of hearing loss. The I-L curve is more accurate than ABR threshold diagrams to identify minor electrophysiological changes of the cochlea.

Place, publisher, year, edition, pages
1998. Vol. 8, no 2, 59-65 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-58766DOI: 10.1159/000027813OAI: oai:DiVA.org:uu-58766DiVA: diva2:86675
Available from: 2008-10-17 Created: 2008-10-17 Last updated: 2010-12-16Bibliographically approved

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