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Programmed cell death in the developing epithelium of the mouse inner ear
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences. (Oto-Rhino-Laryngology, Head & Neck Surgery)
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1998 (English)In: Acta Oto-Laryngologica, ISSN 0001-6489, Vol. 118, no 1, 96-100 p.Article in journal (Refereed) Published
Abstract [en]

Programmed cell death is as essential to development as is proliferation. Thus, the objective of this study was to elucidate the spatiotemporal involvement of programmed cell death in the development of the inner ear epithelia. Programmed cell death is seen in situ as apoptosis. A time-sequence study was performed on the distribution of apoptosis during the development of the inner ear epithelia of the mouse using the TdT-mediated dUTP-biotin nick labeling (TUNEL) method to detect apoptosis histochemically. Apoptosis occurred during the early stages of development of the inner ear and took place earlier in the organs of equilibrium than in the cochlea. These periods corresponded to those of active proliferation of epithelial cells in the inner ear. Since cell-cell interactions change after the removal of neighboring cells by apoptosis, apoptosis may influence cytodifferentiation.

Place, publisher, year, edition, pages
1998. Vol. 118, no 1, 96-100 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-58768PubMedID: 9504171OAI: oai:DiVA.org:uu-58768DiVA: diva2:86677
Available from: 2008-10-17 Created: 2008-10-17 Last updated: 2010-03-03Bibliographically approved

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