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Regulation of Instant Blood Mediated Inflammatory Reaction (IBMIR) in Pancreatic Islet Xeno-Transplantation: Points for Therapeutic Interventions
Tech Univ Dresden, Fac Med, Dept Clin Pathobiochem, D-01307 Dresden, Germany..
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Clinical Immunology.
Tech Univ Dresden, Fac Med, Dept Clin Pathobiochem, D-01307 Dresden, Germany..
Univ Penn, Perelman Sch Med, Philadelphia, PA 19104 USA..
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2015 (English)In: IMMUNE RESPONSES TO BIOSURFACES: MECHANISMS AND THERAPEUTIC INTERVENTIONS / [ed] Lambris, JD; Ekdahl, KN; Ricklin, D; Nilsson, B, 2015, 171-188 p.Conference paper, Published paper (Refereed)
Abstract [en]

Xeno-transplantation of pancreatic islets represents a promising therapeutic alternative for the treatment of type 1 diabetes mellitus. However, potent innate immune responses induced shortly after the transplantation of donor islets to the recipient, comprising the Instant Blood Mediated Immune Reaction (IBMIR), exert detrimental actions on islet graft function. The coagulation and complement cascades together with the leukocyte and platelet populations are the major players in IBMIR. This innate immune attack affects dramatically islet integrity and leads to significant loss of function of the xenograft. In the present review, we focus on the mechanisms contributing to IBMIR components and address therapeutic intervention approaches to limit IBMIR by administering inhibitors in circulation, by coating the islet surface with inhibitors or by generating transgenic donor animals; these approaches could result in improved xenograft survival.

Place, publisher, year, edition, pages
2015. 171-188 p.
Series
Advances in Experimental Medicine and Biology, ISSN 0065-2598 ; 865
Keyword [en]
Instant blood mediated immune reaction (IBMIR), Coagulation, Complement, Islet xenotransplantation, Compstatin
National Category
Immunology in the medical area
Identifiers
URN: urn:nbn:se:uu:diva-265643DOI: 10.1007/978-3-319-18603-0_11ISI: 000361838300012PubMedID: 26306450ISBN: 978-3-319-18603-0 (print)ISBN: 978-3-319-18602-3 (print)OAI: oai:DiVA.org:uu-265643DiVA: diva2:866789
Conference
1st International Conference on Immune Response to Biosurfaces, SEP 27-OCT 02, 2014, Chania, GREECE
Funder
EU, FP7, Seventh Framework Programme, 602699German Research Foundation (DFG), SFB-TRR 127
Available from: 2015-11-03 Created: 2015-11-02 Last updated: 2015-11-05Bibliographically approved

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Magnusson, Peetra U.

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