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Lipopolysaccharide-induced expression of nitric oxide synthase II in the guinea pig vestibular end organ
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences. (Oto-Rhino-Laryngology, Head & Neck Surgery)
1998 (English)In: European Archives of Oto-Rhino-Laryngology, ISSN 0937-4477, Vol. 255, no 4, 184-8 p.Article in journal (Refereed) Published
Abstract [en]

The purpose of the investigation was to ascertain whether inoculation of bacterial lipopolysaccharide (LPS) into the vestibular organ of the guinea pig might induce formation of nitric oxide synthase (NOS) II. Forty-eight hours after the animals were injected with 1 mg transtympanic LPS, varying degrees of impaired caloric responses were observed with similar degeneration of vestibular hair cells. These effects could be blocked with N-nitro-L-arginine methylester, a competitive inhibitor of NOS. Findings suggested that NOS II, which was not normally detectable in the guinea pig vestibular organ but was present following inoculation of LPS, produced the nitric oxide as the toxic factor causing cell damage. If true, LPS may represent a reproducible method for studying the vestibular pathogenesis of inner ear disease.

Place, publisher, year, edition, pages
1998. Vol. 255, no 4, 184-8 p.
Keyword [en]
Nitric oxide synthase, Bacterial lipopolysaccharide, Vestibular organ pathology, Immunohistochemistry, Guinea pig
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-58770DOI: 10.1007/s004050050040PubMedID: 9592675OAI: oai:DiVA.org:uu-58770DiVA: diva2:86679
Available from: 2008-10-17 Created: 2008-10-17 Last updated: 2010-02-19Bibliographically approved

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