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Signatures of post-zygotic structural genetic aberrations in the cells of histologically normal breast tissue that can predispose to sporadic breast cancer
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Medicinsk genetik och genomik. Uppsala University, Science for Life Laboratory, SciLifeLab.ORCID iD: 0000-0002-1701-755X
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Medicinsk genetik och genomik. Uppsala University, Science for Life Laboratory, SciLifeLab.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Medicinsk genetik och genomik. Uppsala University, Science for Life Laboratory, SciLifeLab.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Medicinsk genetik och genomik. Uppsala University, Science for Life Laboratory, SciLifeLab.
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2015 (English)In: Genome Research, ISSN 1088-9051, E-ISSN 1549-5469, Vol. 25, no 10, 1521-1535 p.Article in journal (Refereed) Published
Abstract [en]

Sporadic breast cancer (SBC) is a common disease without robust means of early risk prediction in the population. We studied 282 females with SBC, focusing on copy number aberrations in cancer-free breast tissue (uninvolved margin, UM) outside the primary tumor (PT). In total, 1162 UMs (1-14 per breast) were studied. Comparative analysis between UM(s), PT(s), and blood/skin from the same patient as a control is the core of the study design. We identified 108 patients with at least one aberrant UM, representing 38.3% of cases. Gains in gene copy number were the principal type of mutations in microscopically normal breast cells, suggesting that oncogenic activation of genes via increased gene copy number is a predominant mechanism for initiation of SBC pathogenesis. The gain of ERBB2, with overexpression of HER2 protein, was the most common aberration in normal cells. Five additional growth factor receptor genes (EGFR, FGFR1, IGF1R, LIFR, and NGFR) also showed recurrent gains, and these were occasionally present in combination with the gain of ERBB2. All the aberrations found in the normal breast cells were previously described in cancer literature, suggesting their causative, driving role in pathogenesis of SBC. We demonstrate that analysis of normal cells from cancer patients leads to identification of signatures that may increase risk of SBC and our results could influence the choice of surgical intervention to remove all predisposing cells. Early detection of copy number gains suggesting a predisposition toward cancer development, long before detectable tumors are formed, is a key to the anticipated shift into a preventive paradigm of personalized medicine for breast cancer.

Place, publisher, year, edition, pages
2015. Vol. 25, no 10, 1521-1535 p.
National Category
Cancer and Oncology
Identifiers
URN: urn:nbn:se:uu:diva-265683DOI: 10.1101/gr.187823.114ISI: 000362157400016PubMedID: 26430163OAI: oai:DiVA.org:uu-265683DiVA: diva2:866903
Funder
Swedish Cancer SocietySwedish Research CouncilSwedish Heart Lung FoundationScience for Life Laboratory - a national resource center for high-throughput molecular bioscience
Note

De 2 första författarna delar förstaförfattarskapet.

Available from: 2015-11-04 Created: 2015-11-02 Last updated: 2017-12-01Bibliographically approved

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Forsberg, Lars A.Rasi, ChiaraPekar, GyulaDavies, HannaLau Börjesson, JoeyHallberg, GunillaJanson, Eva TiensuuDumanski, Jan P.

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Forsberg, Lars A.Rasi, ChiaraPekar, GyulaDavies, HannaLau Börjesson, JoeyHallberg, GunillaJanson, Eva TiensuuDumanski, Jan P.
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Medicinsk genetik och genomikScience for Life Laboratory, SciLifeLabDepartment of Medical Cell BiologyDepartment of Women's and Children's HealthDepartment of Medical Sciences
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