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Recurrent respiratory papillomatosis in northern Sweden: Clinical characteristics and practical guidance
Umea Univ, Dept Clin Sci, Div Otorhinolaryngol, SE-90185 Umea, Sweden..
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Otolaryngology and Head and Neck Surgery. Umea Univ, Dept Clin Sci, Div Otorhinolaryngol, SE-90185 Umea, Sweden..
Umea Univ, Dept Clin Sci, Div Otorhinolaryngol, SE-90185 Umea, Sweden..
Umea Univ, Dept Radiat Sci, Div Oncol, SE-90185 Umea, Sweden..
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2015 (English)In: Acta Oto-Laryngologica, ISSN 0001-6489, E-ISSN 1651-2251, Vol. 135, no 10, 1058-1064 p.Article in journal (Refereed) Published
Abstract [en]

Conclusion: Recurrent respiratory papillomatosis (RRP) patients with high surgical treatment frequency (>= 1/year, HF) were significantly younger and had a more widespread laryngeal disease compared to a low frequency treated group (< 1 treatment/year, LF). This study confirms the existence of a clinical RRP group, not primarily related to HPV sub-type, but more care-intensive and in need of more vigilant follow-up. Objectives: RRP is associated with high morbidity due to its influence on breathing and voice. The purpose of this study was to characterize RRP patients in northern Sweden and investigate possible predictor factors affecting therapeutic needs. Method: Patients from the regional referral area (northern Sweden) were categorized for age, disease duration, juvenile or adult onset, profile of disease development, number of surgical sessions in relation to disease duration, laryngeal deposition of papilloma, gender, and HPV sub-types, in order to identify patients with increased need for frequent surgical treatment. Results: The median age of the RRP patients (n = 48) was 44.5 years; 34 (71%) were males and 14 (29%) females, most were infected with HPV 6. Patients with high surgical treatment frequency/year were significantly younger and showed more widespread papillomatous vegetation in the larynx, compared to the low frequency treated group.

Place, publisher, year, edition, pages
2015. Vol. 135, no 10, 1058-1064 p.
Keyword [en]
Human papilloma virus, recurrent respiratory papillomatosis, HPV vaccine, tonsillar cancer, gender, airway surgery, data analysis
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URN: urn:nbn:se:uu:diva-265637DOI: 10.3109/00016489.2015.1048378ISI: 000361294200014PubMedID: 26004132OAI: oai:DiVA.org:uu-265637DiVA: diva2:866921
Available from: 2015-11-04 Created: 2015-11-02 Last updated: 2015-11-04Bibliographically approved

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Laurell, Göran
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