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Influenza A virus evolution and spatio-temporal dynamics in Eurasian wild birds: a phylogenetic and phylogeographical study of whole-genome sequence data
Univ Cambridge, Dept Zool, Cambridge CB2 3EJ, England..
Erasmus MC, Dept Virosci, NL-3000 CA Rotterdam, Netherlands..
Ilia State Univ, Inst Ecol, Tbilisi, Rep of Georgia..
Univ Cambridge, Dept Vet Med, Cambridge CB3 0ES, England..
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2015 (English)In: Journal of General Virology, ISSN 0022-1317, E-ISSN 1465-2099, Vol. 96, p. 2050-2060Article in journal (Refereed) Published
Abstract [en]

Low pathogenic avian influenza A viruses (IAVs) have a natural host reservoir in wild waterbirds and the potential to spread to other host species. Here, we investigated the evolutionary, spatial and temporal dynamics of avian IAVs in Eurasian wild birds. We used whole-genome sequences collected as part of an intensive long-term Eurasian wild bird surveillance study, and combined this genetic data with temporal and spatial information to explore the virus evolutionary dynamics. Frequent reassortment and co-circulating lineages were observed for all eight genomic RNA segments over time. There was no apparent species-specific effect on the diversity of the avian IAVs. There was a spatial and temporal relationship between the Eurasian sequences and significant viral migration of avian lAVs from West Eurasia towards Central Eurasia. The observed viral migration patterns differed between segments. Furthermore, we discuss the challenges faced when analysing these surveillance and sequence data, and the caveats to be borne in mind when drawing conclusions from the apparent results of such analyses.

Place, publisher, year, edition, pages
2015. Vol. 96, p. 2050-2060
National Category
Infectious Medicine
Identifiers
URN: urn:nbn:se:uu:diva-265933DOI: 10.1099/vir.0.000155ISI: 000362243000007PubMedID: 25904147OAI: oai:DiVA.org:uu-265933DiVA, id: diva2:866950
Funder
NIH (National Institute of Health), HHSN266200700010CNIH (National Institute of Health), HHSN272201400008CNIH (National Institute of Health), HHSN272201400006CNIH (National Institute of Health), HHSN272200900007CWellcome trust, WT089235MFEU, European Research Council, 044490NIH (National Institute of Health), HHSN266200700010CSwedish Research CouncilSwedish Research Council FormasAvailable from: 2015-11-04 Created: 2015-11-04 Last updated: 2017-12-01Bibliographically approved

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