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Incidence of bone metastases and survival after a diagnosis of bone metastases in breast cancer patients
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Endocrine Surgery.
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2014 (English)In: Cancer Epidemiology, ISSN 1877-7821, Vol. 38, no 4, 427-434 p.Article in journal (Refereed) Published
Abstract [en]

Background: Bone is the most common metastatic site associated with breast cancer. Using a database of women with breast cancer treated at Guy's Hospital, London 1976–2006 and followed until end 2010, we determined incidence of and survival after bone metastases. Methods: We calculated cumulative incidence of bone metastases considering death without prior bone metastases as a competing risk. Risk of bone metastases was modelled through Cox-regression. Survival after bone metastases diagnosis was calculated using Kaplan–Meier methodology. Results: Of the 7064 women, 589 (22%) developed bone metastases during 8.4 years (mean). Incidence of bone metastases was significantly higher in younger women, tumour size >5 cm, higher tumour grade, lobular carcinoma and ≥four positive nodes, but was not affected by hormone receptor status. Median survival after bone metastases diagnosis was 2.3 years in women with bone-only metastases compared with <1 year in women with visceral and bone metastases. There was a trend for decreased survival for patients who developed visceral metastases early, and proportionately fewer patients in this group. Interpretation: Incidence of bone metastases has decreased but bone metastases remain a highly relevant clinical problem due to the large number of patients being diagnosed with breast cancer.

Place, publisher, year, edition, pages
2014. Vol. 38, no 4, 427-434 p.
Keyword [en]
Breast cancer; Bone metastases; Survival; Incidence
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-266106DOI: 10.1016/j.canep.2014.05.005OAI: oai:DiVA.org:uu-266106DiVA: diva2:867468
Available from: 2015-11-05 Created: 2015-11-05 Last updated: 2015-11-05

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Holmberg, Lars
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Endocrine Surgery
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