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Low birthweight is associated with an increased risk of LADA and type 2 diabetes: results from a Swedish case-control study
Karolinska Inst, Inst Environm Med, Epidemiol Unit, S-17177 Stockholm, Sweden..
Karolinska Inst, Inst Environm Med, Unit Cardiovasc Epidemiol, S-17177 Stockholm, Sweden..
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Transplantation and regenerative medicine.
Lund Univ, Clin Res Ctr, Dept Clin Sci Malmo, Malmo, Sweden..
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2015 (English)In: Diabetologia, ISSN 0012-186X, E-ISSN 1432-0428, Vol. 58, no 11, 2525-2532 p.Article in journal (Refereed) Published
Abstract [en]

Aims/hypothesis Our aim was to investigate the association between birthweight and latent autoimmune diabetes in adults (LADA), a common diabetes form with features of both type 1 and type 2 diabetes. Methods We used data from the Epidemiological Study of Risk Factors for LADA and Type 2 Diabetes (ESTRID), a Swedish population-based study. Eligible for the analysis were 134 incident LADA cases (glutamic acid decarboxylase antibody [GADA] positive), 350 incident type 2 diabetes cases (GADA negative) and 603 randomly selected controls. We present ORs and 95% CIs for LADA and type 2 diabetes in relation to birthweight, adjusted for sex, age, BMI and family history of diabetes. Results Low birthweight increased the risk of LADA as well as the risk of type 2 diabetes; OR per kg reduction was estimated as 1.52 (95% CI 1.12, 2.08) and 1.58 (1.23, 2.04), respectively. The OR for participants weighing < 3 kg compared with >= 4 kg at birth was estimated as 2.38 (1.23, 4.60) for LADA and 2.37 (1.37, 4.10) for type 2 diabetes. A combination of low birthweight (< 3 kg) and current overweight (BMI >= 25) further augmented the risk: LADA, OR 3.26 (1.69, 6.29); and type 2 diabetes, OR 39.93 (19.27, 82.71). Family history of diabetes had little impact on these estimates. Conclusions/interpretation Our results suggest that low birthweight may be a risk factor for LADA of the same strength as for type 2 diabetes. These findings support LADA, despite its autoimmune component, having an aetiology that includes factors related to type 2 diabetes.

Place, publisher, year, edition, pages
2015. Vol. 58, no 11, 2525-2532 p.
Keyword [en]
Birthweight, BMI, Case-control study, Interaction, LADA, Latent autoimmune diabetes in adults, Type 2 diabetes
National Category
Endocrinology and Diabetes
URN: urn:nbn:se:uu:diva-265662DOI: 10.1007/s00125-015-3711-8ISI: 000361993000009PubMedID: 26208603OAI: oai:DiVA.org:uu-265662DiVA: diva2:867487
Available from: 2015-11-05 Created: 2015-11-02 Last updated: 2015-11-05Bibliographically approved

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Carlsson, Per-OlaMartinell, Mats
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