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Interactions of Antimicrobial Peptides with Bacterial Membranes and Membrane Components
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmacy.
2015 (English)In: Current Topics in Medicinal Chemistry, ISSN 1568-0266, E-ISSN 1873-4294, Vol. 16, no 1, 16-24 p.Article, review/survey (Refereed) Published
Abstract [en]

Antimicrobial peptides (AMPs) have attracted considerable recent interest as potential therapeutics, motivated by increasing resistance development against conventional antibiotics. This brief overview summarizes some key aspects related to the interaction of AMPs with bacterial and cell membranes, as well as with membrane components, which is at the core of the mode-of-action of these compounds. Throughout, studies on peptide interactions with model lipid membranes and membrane components are correlated to biological results on antimicrobial and anti-inflammatory effects of AMPs, and translated into therapeutic considerations.

Place, publisher, year, edition, pages
Uppsala Univ, Dept Pharm, SE-75123 Uppsala, Sweden., 2015. Vol. 16, no 1, 16-24 p.
Keyword [en]
AMP, Anti-inflammatory, Antimicrobial, Bacteria, Membrane, Peptide
National Category
Pharmaceutical Sciences
Identifiers
URN: urn:nbn:se:uu:diva-266069DOI: 10.2174/1568026615666150703121518ISI: 000361741400004PubMedID: 26139113OAI: oai:DiVA.org:uu-266069DiVA: diva2:867594
Funder
Swedish Research Council, 2012-1842
Available from: 2015-11-05 Created: 2015-11-05 Last updated: 2017-12-01Bibliographically approved

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Malmsten, Martin

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