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Effect of spasmolytic drugs on esophageal foreign bodies:  A multicenter placebo controlled double-blind study of glucagon and diazepam
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences. (Oto-Rhino-Laryngology, Head & Neck Surgery)
1995 (English)In: Dysphagia (New York. Print), ISSN 0179-051X, Vol. 10, no 2, 126-7 p.Article in journal (Refereed) Published
Abstract [en]

Muscle spasm has been proposed as the cause for esophageal food impaction. The aim was therefore to treat esophageal foreign bodies with spasmolytic drugs influencing both striated and smooth muscles of the esophagus. A multicenter, placebo-controlled, double-blind study of glucagon and diazepam was undertaken in 43 patients. The foreign body disimpacted in 9 of 24 patients given active substances and in 6 of 19 patients given placebo; there was no significant difference between these two groups. Almost all disimpactions occurred several hours after injection of the drugs. The hypothesis of muscle spasm as an important cause of esophageal obstruction was rejected. Medical therapies for food disimpaction other than spasmolytic drugs have to be investigated.

Place, publisher, year, edition, pages
1995. Vol. 10, no 2, 126-7 p.
Keyword [en]
Diazepam, Deglutition, Deglutition disorders, Esophagus obstruction, Foreign body, Glucagon, Hiatal hernia, Spasmolytics, Stricture
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-58864DOI: 10.1007/BF00440084PubMedID: 7600855OAI: oai:DiVA.org:uu-58864DiVA: diva2:86773
Available from: 2008-10-17 Created: 2008-10-17 Last updated: 2010-03-04Bibliographically approved

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