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Alpha-Bungarotoxin Inhibits Outer Hair Cell Motility in situ
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences. (Oto-Rhino-Laryngology, Head & Neck Surgery)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences. (Oto-Rhino-Laryngology, Head & Neck Surgery)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences. (Oto-Rhino-Laryngology, Head & Neck Surgery)
1995 (English)In: Journal for Oto-Rhino-Laryngology, ISSN 0301-1569, E-ISSN 1423-0275, Vol. 57, no 2, 105-109 p.Article in journal (Refereed) Published
Abstract [en]

The effect of two substances (alpha-bungarotoxin, alpha-BGTX, a small protein, and the local anesthetic bupivacaine hydrochloride) with an assumed effect on outer hair cell (OHC) motility were analyzed after exposing the cochlea via the round window membrane. Electrophysiological measurements were performed with a very narrow frequency-specific gating (+/- 100 Hz) technique to determine auditory brainstem response (ABR) thresholds, including ABR-based frequency tuning curves. Exposure to alpha-BGTX gave a minor improvement in thresholds, interpreted as a facilitation of OHCs, i.e. releasing their efferent inhibitory control, whereas exposure to bupivacaine hydrochloride impaired ABR thresholds, possibly due to immobilization of OHC motility via the lateral cell membrane. Our results are consistent with the hypothesis that efferent influence on the cochlea may be linked with a modulation of the mechanical function of OHCs. We can now postulate that there is in vivo evidence that acetylcholine exerts its effect at the OHCs via an alpha-BGTX alpha-BGTX binding acetylcholine receptor.

Place, publisher, year, edition, pages
1995. Vol. 57, no 2, 105-109 p.
Keyword [en]
Labyrinth, Electrophysiology, Outer hair cell, Motility, Marcain, α-Bungarotoxin, Acetylcholine, Subsurface cisternae
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-58865DOI: 10.1159/000276720PubMedID: 7731658OAI: oai:DiVA.org:uu-58865DiVA: diva2:86774
Available from: 2008-10-17 Created: 2008-10-17 Last updated: 2017-12-01Bibliographically approved

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