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Optogenetic Manipulation of Phosphoinositides
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology. Yale Univ, Dept Cell Biol, Program Cellular Neurosci Neurodegenerat & Repair, Sch Med, New Haven, CT 06520 USA.;Yale Univ, Sch Med, Howard Hughes Med Inst, New Haven, CT 06520 USA..
2015 (English)In: The FASEB Journal, ISSN 0892-6638, E-ISSN 1530-6860, Vol. 29, no 1 SupplementArticle in journal, Meeting abstract (Other academic) Published
Abstract [en]

Phosphoinositides, the phosphorylated products of inositol phospholipids, play critical regulatory roles in cell physiology. Through interactions mediated by their cytosolically exposed and differentially phosphorylated head groups they help control membrane-cytosol interactions. As each of the 7 phosphoinositide species has a unique subcellular localization, they also help define specific interaction ofdifferent membranes. The elucidation of phosphoinositide functions greatly benefit from methodologies to manipulate their concentrations within specific membranes with high spatial and temporal precision. The talk will discuss the useof the blue light-dependent CRY2-CIB1 dimerization modules (1,2) to rapidly and reversibly relocate phosphoinositide-metabolizing enzymes to control specific phosphoinositide dependent reactions within cellular membranes.

Place, publisher, year, edition, pages
2015. Vol. 29, no 1 Supplement
National Category
Cell and Molecular Biology
URN: urn:nbn:se:uu:diva-266287ISI: 000361470502413OAI: oai:DiVA.org:uu-266287DiVA: diva2:867768
Available from: 2015-11-06 Created: 2015-11-06 Last updated: 2015-11-06Bibliographically approved

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