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Cochlear changes after lateral and posterior semicircular canal destruction in healthy and previously toxin exposed rats: An electrophysiological and morphological investigation
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Otolaryngology and Head and Neck Surgery.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Otolaryngology and Head and Neck Surgery.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Otolaryngology and Head and Neck Surgery.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Otolaryngology and Head and Neck Surgery.
1997 (English)In: Acta Oto-Laryngologica, ISSN 0001-6489, E-ISSN 1651-2251, Vol. 117, no 5, 681-688 p.Article in journal (Refereed) Published
Abstract [en]

One group of Sprague-Dawley rats (group A, n = 6) was treated by instilling Pseudomonas aeruginosa exotoxin A (PaExoA), and another (group B, n = 6) treated similarly with Haemophilus influenzae type b endotoxin (HiBEndo). In group A a 20 dB hearing loss was observed, predominantly in the high-frequency region, which was reversible within 1 month. In group B no significant hearing impairment was noted. Between 1 and 6 months later, the lateral and posterior semicircular canals (SCCs) were ablated unilaterally. Control rats (group C, n = 8) were subjected to ablation only. All rats were cochleotomized contralaterally prior to labyrinthine surgery. Frequency-specific evoked potential testing at 2-31.5 kHz tone bursts was performed before and directly after surgery, 6, 24 and 48 hours and 1, 4 and 16 weeks postoperatively. After surgery in 18 rats, thresholds rose immediately, predominantly at 2, 4 and 6 kHz, followed by varying degrees of recovery. Greatest immediate postoperative hearing loss was observed in group A; no rat recovered completely and two rats showed severe permanent threshold elevation. All group B rats recovered completely, except one showing moderate threshold impairment. No permanent hearing loss was observed in group C. This study shows that destruction of SCCs in rats does not necessarily cause permanent hearing loss, even if the fluid spaces are not sealed off. However, previous exposure of the middle ear to PaExoA (but not HiBEndo) renders the cochlea more vulnerable and can result in persistent hearing loss.

Place, publisher, year, edition, pages
1997. Vol. 117, no 5, 681-688 p.
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-58874DOI: 10.3109/00016489709113460PubMedID: 9349863OAI: oai:DiVA.org:uu-58874DiVA: diva2:86783
Available from: 2008-10-17 Created: 2008-10-17 Last updated: 2017-12-01Bibliographically approved

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