uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Virological, biochemical and histological effects of human lymphoblastoid interferon in Swedish patients with chronic hepatitis
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
Show others and affiliations
1997 (English)In: Journal of Viral Hepatitis, ISSN 1352-0504, E-ISSN 1365-2893, Vol. 4, no 5, 325-331 p.Article in journal (Refereed) Published
Abstract [en]

Thirty-eight Swedish patients with chronic hepatitis C were randomly assigned to receive either 3 million units (MU) or 5 MU of human lymphoblastoid interferon-alpha-n1 (Wellferon) three times per week for either 6 or 12 months. The patients were monitored biochemically, histologically and by quantitative polymerase chain reaction for circulating HCV RNA, during therapy and for the following year. Overall, 22 (58%) of the patients lost detectable hepatitis C virus (HCV) viraemia during therapy but eight of these patients relapsed during follow-up, leaving 14 (37%) sustained responders. Patients infected with HCV non-type 1 genotypes were significantly more likely to achieve a sustained response than were those infected with HCV type 1 (63% vs 10.5%, P = 0.001). Sustained virological responses were also associated with lower pretreatment viraemia level, younger age, absence of cirrhosis and the higher interferon dosage regimens but these associations failed to reach statistical significance. In 97% of patients there was concordance between virological and biochemical responses, and a statistically significant (P = 0.005) improvement in the Knodell histological activity index was observed in the virological sustained responders.

Place, publisher, year, edition, pages
1997. Vol. 4, no 5, 325-331 p.
Keyword [en]
genotype, hepatitis C, histology, lymphoblastoid interferon, PCR
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-58877DOI: 10.1046/j.1365-2893.1997.00061.xPubMedID: 9310931OAI: oai:DiVA.org:uu-58877DiVA: diva2:86786
Available from: 2008-10-17 Created: 2008-10-17 Last updated: 2010-10-06Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed
By organisation
Department of Medical Sciences
In the same journal
Journal of Viral Hepatitis
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 146 hits
ReferencesLink to record
Permanent link

Direct link