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Big Data: the challenge for small research groups in the era of cancer genomics
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Endocrine Surgery.
2015 (English)In: British Journal of Cancer, ISSN 0007-0920, E-ISSN 1532-1827, Vol. 113, no 10, 1405-1412 p.Article, review/survey (Refereed) Published
Abstract [en]

In the past decade, cancer research has seen an increasing trend towards high-throughput techniques and translational approaches. The increasing availability of assays that utilise smaller quantities of source material and produce higher volumes of data output have resulted in the necessity for data storage solutions beyond those previously used. Multifactorial data, both large in sample size and heterogeneous in context, needs to be integrated in a standardised, cost-effective and secure manner. This requires technical solutions and administrative support not normally financially accounted for in small- to moderate-sized research groups. In this review, we highlight the Big Data challenges faced by translational research groups in the precision medicine era; an era in which the genomes of over 75 000 patients will be sequenced by the National Health Service over the next 3 years to advance healthcare. In particular, we have looked at three main themes of data management in relation to cancer research, namely (1) cancer ontology management, (2) IT infrastructures that have been developed to support data management and (3) the unique ethical challenges introduced by utilising Big Data in research.

Place, publisher, year, edition, pages
2015. Vol. 113, no 10, 1405-1412 p.
Keyword [en]
cancer research; database management systems; biobanking; genomics; ontology management; data ethics
National Category
Cancer and Oncology
URN: urn:nbn:se:uu:diva-266733DOI: 10.1038/bjc.2015.341ISI: 000365350300001PubMedID: 26492224OAI: oai:DiVA.org:uu-266733DiVA: diva2:868390
Available from: 2015-11-10 Created: 2015-11-10 Last updated: 2016-02-23Bibliographically approved

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