uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Variation in the Efficacy of Hormone Replacement Therapy in the Prevention of Hip Fracture
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences. (Orthopaedics)
Show others and affiliations
1998 (English)In: Osteoporosis International, ISSN 0937-941X, Vol. 8, no 6, 540-546 p.Article in journal (Refereed) Published
Abstract [en]

Use of postmenopausal hormone replacement therapy (HRT) has been associated with a reduced risk of osteoporotic fractures. However, it is uncertain whether this risk reduction is modified by other risk factors for hip fracture. In a population-based case-control study in Sweden, we investigated the association between HRT and hip fracture risk within categories of age, body measures and lifestyle factors in postmenopausal women, 50-81 years of age. Mailed questionnaires and telephone interviews were used to collect data. Of those eligible, 1328 incident cases with hip fracture (82.5%) and 3312 randomly selected controls (81.6%) answered the questionnaire. Ever use of HRT in women less than 75 years old was associated with an odds ratio (OR) of 0.66 (95% confidence interval: 95% CI 0.50-0.87) for hip fracture compared with OR 0.40 (95% CI 0.21-0.77) in women 75 years or older. We found a significant interaction between HRT and both weight and physical activity (p < 0.05). The protective effect of HRT was particularly pronounced in lean women: compared with never HRT users, ever users weighing under 60 kg had an OR of 0.44 (95% CI 0.30-0.66) whereas women weighing more than 70 kg had an OR of 0.91 (95% CI 0.53-1.56). Women with low recent leisure physical activity (less than 1 h/week) similarly benefited more from HRT for hip fracture prevention than women with a higher degree of recreational physical activity. The observed interactions with weight and physical activity suggest that HRT has the best protective effect against hip fracture among high-risk women.

Place, publisher, year, edition, pages
1998. Vol. 8, no 6, 540-546 p.
Keyword [en]
Estrogen, Hip fracture, Hormone replacement therapy, Interaction, Physical activity, Weight
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-59030DOI: 10.1007/s001980050096PubMedID: 10326058OAI: oai:DiVA.org:uu-59030DiVA: diva2:86939
Available from: 2008-10-17 Created: 2008-10-17 Last updated: 2009-10-26Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed
By organisation
Department of Surgical SciencesDepartment of Medical Sciences
In the same journal
Osteoporosis International
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 144 hits
ReferencesLink to record
Permanent link

Direct link