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Endotoxemia and complement activation after severe burn injuries--effects on leukocytes, soluble selectins, and inflammatory cytokines.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology.
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1996 (English)In: Inflammation, ISSN 0360-3997, E-ISSN 1573-2576, Vol. 20, no 3, 229-241 p.Article in journal (Refereed) Published
Abstract [en]

In this study we followed the development of an inflammatory response in a group of patients the first week after a burn injury. We detected elevated plasma endotoxin levels, on at least one occasion, in 6 of 8 patients. No endotoxin was detected in the two patients with the lowest total burned surface area (< or = 30%). We found evidence of complement activation as increased C3a levels, in parallel with a production of inflammatory cytokines (TNF-alpha, IL-6). The TNF-alpha levels increased significantly during the observation period, while the IL-6 levels were elevated already at admission, and remained so. Elevated levels of soluble E-selectin were detected, indicating endothelial cell activation. Despite the inflammatory response and a loss of inflammatory cells during the first days of the monitoring period, we found no evidence of cellular activation measured as increased expression of beta 2 integrin CD11b, nor increased plasma levels of soluble L-selectin.

Place, publisher, year, edition, pages
1996. Vol. 20, no 3, 229-241 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-266916PubMedID: 8796378OAI: oai:DiVA.org:uu-266916DiVA: diva2:869484
Available from: 2015-11-13 Created: 2015-11-13 Last updated: 2015-11-13

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