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Randomized controlled study in pregnancy on treatment of marked hyperglycemia that is short of overt diabetes
Univ Orebro, Sch Hlth & Med Sci, Dept Obstet & Gynecol, SE-70182 Orebro, Sweden..
Univ Orebro, Sch Hlth & Med Sci, Dept Obstet & Gynecol, SE-70182 Orebro, Sweden..
UltraGyn Clin, Stockholm, Sweden..
Karolinska Univ Hosp, Dept Obstet & Gynecol, Stockholm, Sweden..
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2015 (English)In: Acta Obstetricia et Gynecologica Scandinavica, ISSN 0001-6349, E-ISSN 1600-0412, Vol. 94, no 11, 1181-1187 p.Article in journal (Refereed) Published
Abstract [en]

IntroductionA randomized multicenter study was conducted in the Stockholm-orebro areas in Sweden to evaluate how treatment aiming at normoglycemia affects fetal growth, pregnancy and neonatal outcome in pregnant women with severe hyperglycemia. Material and methodsPregnant women with hyperglycemia defined as fasting capillary plasma glucose <7.0 mmol/L and a two-hour plasma glucose value 10.0 and <12.2 mmol/L following a 75-g oral glucose tolerance test (OGTT) diagnosed before 34 weeks of gestation were randomized to treatment (n=33) or controls (n=36). Women assigned to the control group were blinded for the OGTT results and received routine care. The therapeutic goal was fasting plasma glucose 4-5 mmol/L, and <6.5 mmol/L after a meal. Primary outcomes were size at birth and number of large-for-gestational age (>90th percentile) neonates. Secondary outcomes were pregnancy complications, neonatal morbidity and glycemic control. ResultsThe planned number of participating women was not reached. There was a significantly reduced rate of large-for-gestational age neonates, 21 vs. 47%, P<0.05. Group differences in pregnancy complications and neonatal morbidity were not detected because of limited statistical power. In total, 66.7% of the women in the intervention group received insulin. Of all measured plasma glucose values, 64.1% were in the target range, 7.2% in the hypoglycemic range and 28.7% above target values. There were no cases of severe hypoglycemia. ConclusionsAiming for normalized glycemia in a pregnancy complicated by severe hyperglycemia reduces fetal growth but is associated with an increased rate of mild hypoglycemia.

Place, publisher, year, edition, pages
2015. Vol. 94, no 11, 1181-1187 p.
Keyword [en]
Pregnancy, gestational diabetes mellitus, hyperglycemia, treatment, birthweight, compliance, large-for-gestational age
National Category
Obstetrics, Gynecology and Reproductive Medicine
URN: urn:nbn:se:uu:diva-266681DOI: 10.1111/aogs.12717ISI: 000362844400006PubMedID: 26222270OAI: oai:DiVA.org:uu-266681DiVA: diva2:871409
Swedish Diabetes Association
Available from: 2015-11-13 Created: 2015-11-10 Last updated: 2015-11-13Bibliographically approved

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Hanson, Ulf S. B.
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