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Toward the Replacement of Animal Experiments through the Bioinformatics-driven Analysis of 'Omics' Data from Human Cell Cultures
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences. Uppsala University, Science for Life Laboratory, SciLifeLab.ORCID iD: 0000-0002-8083-2864
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2015 (English)In: ATLA (Alternatives to Laboratory Animals), ISSN 0261-1929, Vol. 43, no 5, 325-332 p.Article in journal (Refereed) Published
Abstract [en]

This paper outlines the work for which Roland Grafström and Pekka Kohonen were awarded the 2014 Lush Science Prize. The research activities of the Grafström laboratory have, for many years, covered cancer biology studies, as well as the development and application of toxicity-predictive in vitro models to determine chemical safety. Through the integration of in silico analyses of diverse types of genomics data (transcriptomic and proteomic), their efforts have proved to fit well into the recently-developed Adverse Outcome Pathway paradigm. Genomics analysis within state-of-the-art cancer biology research and Toxicology in the 21st Century concepts share many technological tools. A key category within the Three Rs paradigm is the Replacement of animals in toxicity testing with alternative methods, such as bioinformatics-driven analyses of data obtained from human cell cultures exposed to diverse toxicants. This work was recently expanded within the pan-European SEURAT-1 project (Safety Evaluation Ultimately Replacing Animal Testing), to replace repeat-dose toxicity testing with data-rich analyses of sophisticated cell culture models. The aims and objectives of the SEURAT project have been to guide the application, analysis, interpretation and storage of 'omics' technology-derived data within the service-oriented sub-project, ToxBank. Particularly addressing the Lush Science Prize focus on the relevance of toxicity pathways, a 'data warehouse' that is under continuous expansion, coupled with the development of novel data storage and management methods for toxicology, serve to address data integration across multiple 'omics' technologies. The prize winners' guiding principles and concepts for modern knowledge management of toxicological data are summarised. The translation of basic discovery results ranged from chemical-testing and material-testing data, to information relevant to human health and environmental safety.

Place, publisher, year, edition, pages
2015. Vol. 43, no 5, 325-332 p.
National Category
Bioinformatics (Computational Biology)
Research subject
URN: urn:nbn:se:uu:diva-267052ISI: 000368434900009PubMedID: 26551289OAI: oai:DiVA.org:uu-267052DiVA: diva2:871947
Science for Life Laboratory - a national resource center for high-throughput molecular bioscienceeSSENCE - An eScience CollaborationSwedish Cancer SocietySwedish Research Council
Available from: 2015-11-17 Created: 2015-11-17 Last updated: 2016-02-25Bibliographically approved

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Spjuth, Ola
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