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The CRISPR-Cas immune system: Biology, mechanisms and applications
Bhabha Atom Res Ctr, Div Mol Biol, Mumbai 400085, Maharashtra, India..
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology, Microbiology. Uppsala Univ, Dept Cell & Mol Biol, SE-75124 Uppsala, Sweden..
Univ Mumbai, Dept Biotechnol, Mumbai 400098, Maharashtra, India..
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology, Microbiology.
2015 (English)In: Biochimie, ISSN 0300-9084, E-ISSN 1638-6183, Vol. 117, 119-128 p.Article, review/survey (Refereed) Published
Abstract [en]

Viruses are a common threat to cellular life, not the least to bacteria and archaea who constitute the majority of life on Earth. Consequently, a variety of mechanisms to resist virus infection has evolved. A recent discovery is the adaptive immune system in prokaryotes, a type of system previously thought to be present only in vertebrates. The system, called CRISPR-Cas, provide sequence-specific adaptive immunity and fundamentally affect our understanding of virus host interaction. CRISPR-based immunity acts by integrating short virus sequences in the cell's CRISPR locus, allowing the cell to remember, recognize and clear infections. There has been rapid advancement in our understanding of this immune system and its applications, but there are many aspects that await elucidation making the field an exciting area of research. This review provides an overview of the field and highlights unresolved issues.

Place, publisher, year, edition, pages
2015. Vol. 117, 119-128 p.
Keyword [en]
CRISPR, Cascade, Cas9, Cas3, Cmr/Csm
National Category
Biochemistry and Molecular Biology
Identifiers
URN: urn:nbn:se:uu:diva-266137DOI: 10.1016/j.biochi.2015.03.025ISI: 000361864900013PubMedID: 25868999OAI: oai:DiVA.org:uu-266137DiVA: diva2:871987
Funder
Swedish Research CouncilWenner-Gren Foundations
Available from: 2015-11-17 Created: 2015-11-05 Last updated: 2017-12-01Bibliographically approved

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Amlinger, LinaLundgren, Magnus

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