uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Genetic Polymorphisms in Vitamin D Metabolism and Signaling Genes and Risk of Breast Cancer: A Nested Case-Control Study
NYU, Sch Med, Dept Populat Hlth, New York, NY 10010 USA..
NYU, Sch Med, Dept Populat Hlth, New York, NY 10010 USA..
NYU, Sch Med, Dept Populat Hlth, New York, NY 10010 USA.;NYU, Inst Canc, Sch Med, New York, NY USA..
Uppsala University, Science for Life Laboratory, SciLifeLab. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
Show others and affiliations
2015 (English)In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 10, no 10, e0140478Article in journal (Refereed) Published
Abstract [en]

Genetic polymorphisms in vitamin D metabolism and signaling genes have been inconsistently associated with risk of breast cancer, though few studies have examined SNPs in vitamin D-related genes other than the vitamin D receptor (VDR) gene and particularly have not examined the association with the retinoid X receptor alpha (RXRA) gene which may be a key vitamin D pathway gene. We conducted a nested case-control study of 734 cases and 1435 individually matched controls from a population-based prospective cohort study, the Northern Sweden Mammary Screening Cohort. Tag and functional SNPs were genotyped for the VDR, cytochrome p450 24A1 (CYP24A1), and RXRA genes. We also genotyped specific SNPs in four other genes related to vitamin D metabolism and signaling (GC/VDBP, CYP2R1, DHCR7, and CYP27B1). SNPs in the CYP2R1, DHCR7, and VDBP gene regions that were associated with circulating 25(OH) D concentration in GWAS were also associated with plasma 25(OH) D in our study (p-trend < 0.005). After taking into account the false discovery rate, these SNPs were not significantly associated with breast cancer risk, nor were any of the other SNPs or haplotypes in VDR, RXRA, and CYP24A1. We observed no statistically significant associations between polymorphisms or haplotypes in key vitamin D-related genes and risk of breast cancer. These results, combined with the observation in this cohort and most other prospective studies of no association of circulating 25(OH) D with breast cancer risk, do not support an association between vitamin D and breast cancer risk.

Place, publisher, year, edition, pages
2015. Vol. 10, no 10, e0140478
National Category
Cancer and Oncology
URN: urn:nbn:se:uu:diva-267206DOI: 10.1371/journal.pone.0140478ISI: 000363248400054PubMedID: 26488576OAI: oai:DiVA.org:uu-267206DiVA: diva2:872483
Available from: 2015-11-19 Created: 2015-11-19 Last updated: 2015-11-19Bibliographically approved

Open Access in DiVA

fulltext(348 kB)24 downloads
File information
File name FULLTEXT01.pdfFile size 348 kBChecksum SHA-512
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Axelsson, Tomas
By organisation
Science for Life Laboratory, SciLifeLabDepartment of Medical Sciences
In the same journal
Cancer and Oncology

Search outside of DiVA

GoogleGoogle Scholar
Total: 24 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 136 hits
ReferencesLink to record
Permanent link

Direct link