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Reactivation of human herpesvirus 6 during pregnancy
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health. (Perinatal, neonatal och barnkardiologi/Sedin)
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1999 (English)In: Journal of Infectious Diseases, ISSN 0022-1899, Vol. 180, no 6, 2035-2038 p.Article in journal (Refereed) Published
Abstract [en]

Reactivation of human herpesvirus 6 (HHV-6) and cytomegalovirus (CMV) during pregnancy and transmission of the viruses to the fetus were investigated by polymerase chain reaction (PCR) and serology. In all, 104 blood samples were obtained 3 times during pregnancy and once at delivery. In another 107 women, samples were obtained only at delivery. Cord blood samples were obtained from both groups of women. HHV-6 DNA was detected in 41%-44% of the samples during months 3-8 of pregnancy, in 25% at delivery, and in 24% of age-matched controls. HHV-6 DNA was found in 1.0% of the cord blood samples. CMV DNA was detected in 1.7% of leukocytes from 104 pregnant women but in no cord blood sample. IgG antibodies to HHV-6 were found in 96% and CMV IgG in 62.5% of the women. HHV-6 IgG titers were significantly higher in HHV-6 PCR-positive women. Thus, HHV-6 reactivation seems common during pregnancy, and transfer of HHV-6 to the fetus may occur in approximately 1% of pregnancies.

Place, publisher, year, edition, pages
1999. Vol. 180, no 6, 2035-2038 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-59341DOI: 10.1086/315115PubMedID: 10558965OAI: oai:DiVA.org:uu-59341DiVA: diva2:87250
Available from: 2008-10-17 Created: 2008-10-17 Last updated: 2010-09-30Bibliographically approved

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