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Heroin abuse exaggerates age-related deposition of hyperphosphorylated tau and p62-positive inclusions
Med Univ Vienna, Inst Neurol, A-1097 Vienna, Austria.;Semmelweis Univ, Neuropathol & Prion Dis Reference Ctr, H-1085 Budapest, Hungary..
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Forensic Medicine.
Semmelweis Univ, Neuropathol & Prion Dis Reference Ctr, H-1085 Budapest, Hungary..
Med Univ Vienna, Inst Neurol, A-1097 Vienna, Austria..
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2015 (English)In: Neurobiology of Aging, ISSN 0197-4580, E-ISSN 1558-1497, Vol. 36, no 11, 3100-3107 p.Article in journal (Refereed) Published
Abstract [en]

The observation of increased hyperphosphorylated tau levels correlating with microglial activation in opiate abusers has been interpreted as predisposition to accelerated Alzheimer diseaseerelated changes. The present study focused on evaluating additional neurodegeneration-related proteins, including a-synuclein and TDP-43, and p62-positive deposits. We performed a systematic mapping of protein deposits in the brains of 27 individuals with documented heroin addiction (age: 19-40 years) and compared with 11 controls (age: 15-40 years). We confirm previous findings that heroin addiction associates with tau hyperphosphorylation in predilection brain areas for aging and Alzheimer disease. Furthermore, we show that this occurs also in areas implicated in the molecular disturbances and in vivo neuronal networks related to heroin abuse. There was, however, no presence of amyloid-beta deposits. We extend previous findings by showing the lack of TDP-43 or alpha-synuclein pathology and emphasize the independent effect of the duration of drug use on the appearance of age-related p62-positive neuritic profiles. These observations provide unique insights about neuropathological alterations in the brains of young heroin addicts and have implications about brain aging and the influences of environmental and toxic factors.

Place, publisher, year, edition, pages
2015. Vol. 36, no 11, 3100-3107 p.
Keyword [en]
Aging, alpha-Synuclein, Heroin, Neuropathology, Opiate, Tau, TDP-43, p62
National Category
Other Medical Sciences
URN: urn:nbn:se:uu:diva-267187DOI: 10.1016/j.neurobiolaging.2015.07.018ISI: 000363281700020PubMedID: 26254956OAI: oai:DiVA.org:uu-267187DiVA: diva2:872733
EU, FP7, Seventh Framework Programme, 278486
Available from: 2015-11-20 Created: 2015-11-19 Last updated: 2015-11-20Bibliographically approved

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Horvath, Monika Cs.
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