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Intestinal dysbiosis in children with short bowel syndrome is associated with impaired outcome
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health. (Barnkirurgi/Christofferson)
Karolinska Inst, Dept Microbiol Tumor & Cell Biol, S-17177 Stockholm, Sweden.;Karolinska Inst, Sci Life Lab, S-17177 Stockholm, Sweden..
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health. (Pediatrisk inflammationsforskning/Alving)
Karolinska Inst, Dept Clin Sci & Educ, S-11883 Stockholm, Sweden.;Sachs Childrens & Youth Hosp, S-11883 Stockholm, Sweden..
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2015 (English)In: Microbiome, ISSN 0026-2633, E-ISSN 2049-2618, Vol. 3, UNSP 18Article in journal (Refereed) Published
Abstract [en]

Background: The composition of the intestinal microbiota seems to be an important factor in determining the clinical outcome in children with short bowel syndrome (SBS). Alterations in the microbiota may result in serious complications such as small bowel bacterial overgrowth (SBBO) and intestinal mucosal inflammation that lead to prolonged parenteral nutrition (PN) dependency with subsequently increased risk of liver failure and sepsis. To date, there are no reported mappings of the intestinal microbiome in children with SBS. Here, we present the first report on the intestinal microbial community profile in children with SBS. Findings: The study includes children diagnosed with SBS in the neonatal period. Healthy siblings served as controls. Fecal samples were collected, and microbial profiles were analyzed by using 16S rRNA gene sequencing on the Illumina MiSeq platform. We observed a pronounced microbial dysbiosis in children with SBS on PN treatment with an increased and totally dominating relative abundance of Enterobacteriacae in four out of five children compared to children with SBS weaned from PN and healthy siblings. Conclusions: The overall decreased bacterial diversity in children with SBS is consistent with intestinal microbiome mappings in inflammatory bowel diseases such as Crohn's disease and necrotizing enterocolitis in preterm infants. Our findings indicate that intestinal dysbiosis in children with SBS is associated with prolonged PN dependency.

Place, publisher, year, edition, pages
2015. Vol. 3, UNSP 18
Keyword [en]
Dysbiosis, Short bowel syndrome, Bacterial diversity, Gut microbiota
National Category
Gastroenterology and Hepatology
Identifiers
URN: urn:nbn:se:uu:diva-267352DOI: 10.1186/s40168-015-0084-7ISI: 000363234300001OAI: oai:DiVA.org:uu-267352DiVA: diva2:872794
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Swedish Research Council
Available from: 2015-11-20 Created: 2015-11-20 Last updated: 2017-12-01Bibliographically approved

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Engstrand Lilja, HeleneNyström, Niklas

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