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To Stage Alzheimer's Disease Related Neurodegeneration Using one Section of Hippocampus
Univ Uppsala Hosp, Dept Clin Pathol & Immunol, Uppsala, Sweden..
Univ Helsinki, Fac Med, Dept Publ Hlth, Helsinki, Finland.;Univ Eastern Finland, Inst Clin Med, Neurol, Kuopio, Finland..
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology. Univ Uppsala Hosp, Dept Clin Pathol & Immunol, Uppsala, Sweden..
2015 (English)In: Journal of Alzheimer's Disease, ISSN 1387-2877, E-ISSN 1875-8908, Vol. 48, no 3, 597-601 p.Article in journal (Refereed) Published
Abstract [en]

For Braak staging of Alzheimer's disease (AD), the assessment of only hippocampal section has been proposed. In two published modifications, the emphasis is on the pathology in Ammon's horn. We investigated this approach in a cohort including 150 cases. A Braak stage was possible to assign in a subset of the cases, and the agreement rates varied from 60% to 36%. Thus, to reliably stage the AD-related neurodegeneration, regions such as the entorhinal, transentorhinal, temporo-occipital, and occipital cortices should be assessed as has also been recommended in 2012 by the National Institute on Aging - Alzheimer's Association guidelines.

Place, publisher, year, edition, pages
2015. Vol. 48, no 3, 597-601 p.
Keyword [en]
Alzheimer's disease, ammon's horn, braak stage, hippocampus
National Category
Neurosciences Neurology
Identifiers
URN: urn:nbn:se:uu:diva-267085DOI: 10.3233/JAD-150494ISI: 000362958800004PubMedID: 26402117OAI: oai:DiVA.org:uu-267085DiVA: diva2:872856
Available from: 2015-11-20 Created: 2015-11-17 Last updated: 2017-12-01Bibliographically approved

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Alafuzoff, Irina

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