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The prophylactic effect of doxycycline on postoperative infection rate after first-trimester abortion
1987 (English)In: Obstetrics and Gynecology, ISSN 0029-7844, E-ISSN 1873-233X, Vol. 70, no 5, 755-758 p.Article in journal (Refereed) Published
Abstract [en]

A prospective double-blind study was performed to evaluate the effect of prophylactic antibiotic treatment before induced abortion. Eight hundred consecutive women admitted for first-trimester abortion, without signs of genital infection or antibiotic use in the last three weeks, were included in the study. Doxycycline 400 mg or placebo was given as a single oral dose ten to 12 hours before vacuum aspiration. Ninety-one women (11.8%) returned to the hospital with suspected complications. Thirty-two of these women were diagnosed as having pelvic inflammatory disease, eight of whom (2.1%) had received doxycycline before the abortion and 24 of whom (6.2%) had received placebo, a statistically significant difference (P less than .01). A history of pelvic inflammatory disease increased the risk of developing it again after an abortion.

Place, publisher, year, edition, pages
1987. Vol. 70, no 5, 755-758 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-59418PubMedID: 3658286OAI: oai:DiVA.org:uu-59418DiVA: diva2:87327
Available from: 2008-10-17 Created: 2008-10-17 Last updated: 2012-03-29Bibliographically approved

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Darj, Elisabeth
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