Liver metabolism during treatment with estradiol and progesterone
1993 (English)In: Gynecological Endocrinology, ISSN 0951-3590, E-ISSN 1473-0766, Vol. 7, no 2, 111-114 p.Article in journal (Refereed) Published
Serum concentrations of sex hormone-binding globulin (SHBG), corticosteroid binding globulin (CBG), ceruloplasmin, lipoprotein A and liver enzymes were measured in 30 postmenopausal women treated with 2 mg micronized 17 beta-estradiol daily and micronized progesterone orally in doses of 50, 100 and 200 mg daily, as progestogen supplementation. The treatment lasted for 4 months. The serum levels of SHBG and CBG increased during treatment and a weak association between progesterone dosage and CBG was observed. Levels of lipoprotein A and liver enzymes did not change. It is concluded that micronized natural progesterone is an attractive means of progesterone supplementation in postmenopausal hormone replacement therapy without any liver-related side-effects.
Place, publisher, year, edition, pages
1993. Vol. 7, no 2, 111-114 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-59441DOI: 10.3109/09513599309152489PubMedID: 8213224OAI: oai:DiVA.org:uu-59441DiVA: diva2:87351