uu.seUppsala University Publications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
The phenotype of concurrent chronic bronchitis and frequent exacerbations in patients with severe COPD attending Swedish secondary care units
Univ Orebro, Dept Resp Med, S-70185 Orebro, Sweden..
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Family Medicine and Preventive Medicine.
Karolinska Inst, Inst Environm Med, Unit Lung & Airway Res, S-10401 Stockholm, Sweden..
Karolinska Inst, Inst Environm Med, Unit Lung & Airway Res, S-10401 Stockholm, Sweden..
Show others and affiliations
2015 (English)In: The International Journal of Chronic Obstructive Pulmonary Disease, ISSN 1176-9106, E-ISSN 1178-2005, Vol. 10, 2327-2334 p.Article in journal (Refereed) Published
Abstract [en]

Background: Chronic bronchitis and previous exacerbations are both well-known risk factors for new exacerbations, impaired health-related quality of life, and increased mortality in COPD. The aim of the study was to characterize the phenotype of concurrent chronic bronchitis and frequent exacerbation in severe COPD. Methods: Information on patient characteristics, comorbidity, and exacerbations from the previous year (total number and number requiring hospitalization) was collected from 373 patients with stage III and IV COPD attending 27 secondary care respiratory units in Sweden. Logistic regression used chronic bronchitis and frequent exacerbations (. 2 exacerbations or. 1 hospitalized exacerbations in the previous year) as response variables. Stratification and interaction analyses examined effect modification by sex. Results: Chronic bronchitis was associated with current smoking (adjusted odds ratio [OR] [95% CI], 2.75 [1.54-4.91]; P=0.001), frequent exacerbations (OR [95% CI], 1.93 [1.24-3.01]; P=0.004), and musculoskeletal symptoms (OR [95% CI], 1.74 [1.05-2.86]; P=0.031), while frequent exacerbations were associated with lung function (forced expiratory volume in 1 second as a percentage of predicted value [FEV1% pred]) (OR [95% CI] 0.96 [0.94-0.98]; P=0.001) and chronic bronchitis (OR [95% CI] 1.73 [1.11-2.68]; P=0.015). The phenotype with both chronic bronchitis and frequent exacerbations was associated with FEV1% pred (OR [95% CI] 0.95 [0.92-0.98]; P=0.002) and musculoskeletal symptoms (OR [95% CI] 2.55 [1.31-4.99]; P=0.006). The association of smoking with the phenotype of chronic bronchitis and exacerbations was stronger in women than in men (interaction, P=0.040). Conclusion: Musculoskeletal symptoms and low lung function are associated with the phenotype of combined chronic bronchitis and frequent exacerbations in severe COPD. In women, current smoking is of specific importance for this phenotype. This should be considered in clinical COPD care.

Place, publisher, year, edition, pages
2015. Vol. 10, 2327-2334 p.
Keyword [en]
lung function, smoking, chronic obstructive lung disease, musculoskeletal symptoms
National Category
Respiratory Medicine and Allergy
Identifiers
URN: urn:nbn:se:uu:diva-267590DOI: 10.2147/COPD.S91362ISI: 000363778000001OAI: oai:DiVA.org:uu-267590DiVA: diva2:873709
Available from: 2015-11-24 Created: 2015-11-24 Last updated: 2017-12-01Bibliographically approved

Open Access in DiVA

fulltext(400 kB)65 downloads
File information
File name FULLTEXT01.pdfFile size 400 kBChecksum SHA-512
422b4f2103e5761ec745f5712f64295260559a137651310adcabc949ff9345b35053ff0c1b8e16ce4e6324485523b449f1ed7f4ee7c61e116cbedea55e1731da
Type fulltextMimetype application/pdf

Other links

Publisher's full text

Authority records BETA

Johansson, GunnarJanson, Christer

Search in DiVA

By author/editor
Johansson, GunnarJanson, Christer
By organisation
Family Medicine and Preventive MedicineRespiratory Medicine and Allergology
In the same journal
The International Journal of Chronic Obstructive Pulmonary Disease
Respiratory Medicine and Allergy

Search outside of DiVA

GoogleGoogle Scholar
Total: 65 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
urn-nbn

Altmetric score

doi
urn-nbn
Total: 356 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf