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Impact of ethnicity on progress of glycaemic control in 131 935 newly diagnosed patients with type 2 diabetes: a nationwide observational study from the Swedish National Diabetes Register
Univ Gothenburg, Dept Mol & Clin Med, Gothenburg, Sweden.;Sahlgrens Univ Hosp, Gothenburg, Sweden..
Univ Gothenburg, Dept Mol & Clin Med, Gothenburg, Sweden.;Sahlgrens Univ Hosp, Gothenburg, Sweden.;Ctr Registers, Natl Diabet Register, Gothenburg, Sweden..
Univ Gothenburg, Dept Mol & Clin Med, Gothenburg, Sweden.;Sahlgrens Univ Hosp, Gothenburg, Sweden..
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Geriatrics. Med Prod Agcy, Epidemiol, Uppsala, Sweden..
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2015 (English)In: BMJ Open, ISSN 2044-6055, E-ISSN 2044-6055, Vol. 5, no 6, e007599Article in journal (Refereed) Published
Abstract [en]

Objectives: Studies on ethnic disparities in glycaemic control have been contradictory, and compromised by excessively broad categories of ethnicity and inadequate adjustment for socioeconomic differences. We aimed to study the effect of ethnicity on glycaemic control in a large cohort of patients with type 2 diabetes. Setting: We used nationwide data (mainly from primary care) from the Swedish National Diabetes Register (2002-2011) to identify patients with newly diagnosed (within 12 months) type 2 diabetes. Participants: We included 131 935 patients (with 713 495 appointments), representing 10 ethnic groups, who were followed up to 10 years. Primary and secondary outcome measures: Progress of glycated haemoglobin (HbA1c) for up to 10 years was examined. Mixed models were used to correlate ethnicity with HbA1c (mmol/mol). The effect of glycaemic disparities was examined by assessing the risk of developing albuminuria. The impact of ethnicity was compared to that of income, education and physical activity. Results: Immigrants, particularly those of non-Western origin, received glucose-lowering therapy earlier, had 30% more appointments but displayed poorer glycaemic control (2-5 mmol/mol higher HbA1c than native Swedes). Probability of therapy failure was 28-111% higher for non-Western groups than for native Swedes. High-income Western groups remained below the target-level of HbA1c for 4-5 years, whereas non-Western populations never reached the target level. These disparities translated into 51-92% higher risk of developing albuminuria. The impact of ethnicity was greater than the effect of income and education, and equal to the effect of physical activity. Conclusions: Despite earlier pharmacological treatment and more frequent appointments, immigrants of non-Western origin display poorer glycaemic control and this is mirrored in a higher risk of developing albuminuria.

Place, publisher, year, edition, pages
2015. Vol. 5, no 6, e007599
National Category
Endocrinology and Diabetes
Identifiers
URN: urn:nbn:se:uu:diva-267585DOI: 10.1136/bmjopen-2015-007599ISI: 000363479900066PubMedID: 26048210OAI: oai:DiVA.org:uu-267585DiVA: diva2:873731
Funder
Swedish Heart Lung FoundationSwedish Research Council, 2013-5187Swedish Research Council, 2013-4236
Available from: 2015-11-24 Created: 2015-11-24 Last updated: 2017-12-01Bibliographically approved

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Zethelius, Björn

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