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Control of growth factor binding and release in bisphosphonate functionalized hydrogels guides rapid diff erentiation of precursor cells in vitro
Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Polymer Chemistry. (Jöns Hilborn/Biomaterials)ORCID iD: I-9004-2014
Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Polymer Chemistry. (Jöns Hilborn/Biomaterials)
Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Polymer Chemistry.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Medical Radiation Science. (IGP)
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2016 (English)In: Biomaterials Science, ISSN 2047-4830, E-ISSN 2047-4849, Vol. 4, no 2, 250-254 p.Article in journal (Refereed) Published
Abstract [en]

An in situ cross-linkable hyaluronan hydrogel functionalized with bisphosphonate (BP) groups allows tunable release of bone morphogenetic protein-2 (BMP-2) determined by the amount of BP groups. The high affinity of matrix-anchored BP groups towards BMP-2 permits guided differentiation of entrapped progenitor cells in 3-D cultures.

Place, publisher, year, edition, pages
UK: Royal Society of Chemistry, 2016. Vol. 4, no 2, 250-254 p.
Keyword [en]
bone, hyaluronic acid, bisphosphonates, growth factor, delivery, stem cells
National Category
Polymer Chemistry
Research subject
Chemistry with specialization in Materials Chemistry; Chemistry with specialization in Polymer Chemistry; Biology with specialization in Molecular Biology
Identifiers
URN: urn:nbn:se:uu:diva-267600DOI: 10.1039/c5bm00355eISI: 000368945400005PubMedID: 26610690OAI: oai:DiVA.org:uu-267600DiVA: diva2:873785
Funder
EU, European Research Council, 262948-2EU, FP7, Seventh Framework Programme, 238551
Available from: 2015-11-25 Created: 2015-11-25 Last updated: 2017-12-01Bibliographically approved

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Zhang, YuTolmachev, VladmirHilborn, JönsOssipov, Dmitri

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Kootala, SujitZhang, YuTolmachev, VladmirHilborn, JönsOssipov, Dmitri
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