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Tuberculosis associates with both airflow obstruction and low lung function: BOLD results
Univ London Imperial Coll Sci Technol & Med, Natl Heart & Lung Inst, Resp Epidemiol Occupat Med & Publ Hlth, London SW3 6LR, England..ORCID iD: 0000-0002-0369-9449
Univ London Imperial Coll Sci Technol & Med, Natl Heart & Lung Inst, Resp Epidemiol Occupat Med & Publ Hlth, London SW3 6LR, England..
Univ London Imperial Coll Sci Technol & Med, Natl Heart & Lung Inst, Resp Epidemiol Occupat Med & Publ Hlth, London SW3 6LR, England..
Univ British Columbia, Heart Lung Innovat Ctr, Vancouver, BC V5Z 1M9, Canada..
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2015 (English)In: European Respiratory Journal, ISSN 0903-1936, E-ISSN 1399-3003, Vol. 46, no 4, 1104-1112 p.Article in journal (Refereed) Published
Abstract [en]

In small studies and cases series, a history of tuberculosis has been associated with both airflow obstruction, which is characteristic of chronic obstructive pulmonary disease, and restrictive patterns on spirometry. The objective of the present study was to assess the association between a history of tuberculosis and airflow obstruction and spirometric abnormalities in adults. The study was performed in adults, aged 40 years and above, who took part in the multicentre, cross-sectional, general population-based Burden of Obstructive Lung Disease study, and had provided acceptable post-bronchodilator spirometry measurements and information on a history of tuberculosis. The associations between a history of tuberculosis and airflow obstruction and spirometric restriction were assessed within each participating centre, and estimates combined using meta-analysis. These estimates were stratified by high- and low/middle-income countries, according to gross national income. A self-reported history of tuberculosis was associated with airflow obstruction (adjusted odds ratio 2.51, 95% CI 1.83-3.42) and spirometric restriction (adjusted odds ratio 2.13, 95% CI 1.42-3.19). A history of tuberculosis was associated with both airflow obstruction and spirometric restriction, and should be considered as a potentially important cause of obstructive disease and low lung function, particularly where tuberculosis is common.

Place, publisher, year, edition, pages
2015. Vol. 46, no 4, 1104-1112 p.
National Category
Respiratory Medicine and Allergy
Identifiers
URN: urn:nbn:se:uu:diva-267679DOI: 10.1183/13993003.02325-2014ISI: 000363602700020PubMedID: 26113680OAI: oai:DiVA.org:uu-267679DiVA: diva2:873852
Funder
Wellcome trust, 085790/Z/081ZAstraZenecaGlaxoSmithKline (GSK)
Available from: 2015-11-25 Created: 2015-11-25 Last updated: 2017-12-01Bibliographically approved

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Amaral, Andre F. S.Janson, Christer

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