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Preterm birth may be a larger risk factor for increased blood pressure thanintrauterine growth restriction
Lund Univ, Dept Clin Sci, Lund, Sweden.;Karolinska Univ Hosp, Dept Neonatol, Stockholm, Sweden..
Karolinska Inst Stockholm, Dept Womens & Childrens Hlth, Stockholm, Sweden..
Karolinska Univ Hosp, Dept Neonatol, Stockholm, Sweden.;Karolinska Inst Stockholm, Dept Clin Sci Intervent & Technol, Stockholm, Sweden..
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Pediatrics. Lund Univ, Dept Clin Sci, Lund, Sweden..
2015 (English)In: Acta Paediatrica, ISSN 0803-5253, E-ISSN 1651-2227, Vol. 104, no 11, 1098-1103 p.Article in journal (Refereed) Published
Abstract [en]

AimVery low birthweight (VLBW) and prematurity have been associated with an increased risk of high blood pressure (BP). We compared BP and salivary cortisol responses to a stressful situation between adolescents with a VLBW and controls. MethodsWe compared three groups aged 12-17years: 30 born VLBW but appropriate for gestational age (AGA) at a mean of 27weeks, 19 born VLBW but small for gestational age (SGA) at a mean of 31weeks and 43 term-born AGA controls. Three consecutive BP measurements were performed before a magnetic resonance imaging (MRI) examination. Salivary cortisol and perceived stress were assessed before and after the MRI. ResultsSystolic and diastolic BP decreased significantly for each repeated measurement in the VLBW-SGA group and controls, but remained unchanged in the VLBW-AGA group. The third systolic BP measurement was 9-12mmHg higher in the VLBW-AGA group than the other groups (p<0.05). There were no differences in salivary cortisol between the groups, before and after the MRI or between the sexes. ConclusionDynamic BP responses differed between adolescents born VLBW-AGA and the other groups, indicating that extremely preterm birth may be a larger risk factor for increased BP than intrauterine growth restriction.

Place, publisher, year, edition, pages
2015. Vol. 104, no 11, 1098-1103 p.
Keyword [en]
Gender, Hypertension, Intrauterine growth restriction, Preterm, Stress
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URN: urn:nbn:se:uu:diva-267656DOI: 10.1111/apa.13095ISI: 000363866200022PubMedID: 26094552OAI: oai:DiVA.org:uu-267656DiVA: diva2:873949
Swedish Research Council, 0037
Available from: 2015-11-25 Created: 2015-11-25 Last updated: 2015-11-25Bibliographically approved

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