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Exploring possible association between DβH genotype (C1021T), early onset of conduct disorder and psychopathic traits in juvenile delinquents.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Child and Adolescent Psychiatry.
Yale Univ, Ctr Child Study, New Haven, CT 06520 USA.; Moscow MV Lomonosov State Univ, Moscow, Russia.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Neuro-psycho-pharmacology.
Stockholm Univ, Stockholm, Sweden.; Karolinska Inst, Stockholm, Sweden.
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2016 (English)In: European Archives of Psychiatry and Clinical Neuroscience, ISSN 0940-1334, E-ISSN 1433-8491, Vol. 266, no 8, 771-773 p.Article in journal (Refereed) Published
Abstract [en]

Early onset of conduct disorder (CD) with callous-unemotional traits has been linked to low levels of dopamine β-hydroxylase (DβH), an enzyme involved in dopamine turnover. The C1021T polymorphism in the DβH gene is a major quantitative-trait locus, regulating the level of DβH. In this study of juvenile delinquents from Northern Russia (n = 180), the polymorphism at -1021 was associated neither with early-onset CD nor with psychopathic traits. Association was found between psychopathic traits and early-onset CD, ADHD and mania.

Place, publisher, year, edition, pages
2016. Vol. 266, no 8, 771-773 p.
National Category
Psychiatry
Identifiers
URN: urn:nbn:se:uu:diva-268013DOI: 10.1007/s00406-015-0664-3ISI: 000387495200011PubMedID: 26616837OAI: oai:DiVA.org:uu-268013DiVA: diva2:875446
Funder
The Royal Swedish Academy of Sciences
Available from: 2015-12-01 Created: 2015-12-01 Last updated: 2017-12-01Bibliographically approved

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Isaksson, Johan

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