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Benchmarking biomarker-based criteria for Alzheimer's disease: Data from the Swedish Dementia Registry, SveDem
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2015 (English)In: Alzheimer's & Dementia, ISSN 1552-5260, E-ISSN 1552-5279, Vol. 11, no 12, 1470-1479 p.Article in journal (Refereed) Published
Abstract [en]

INTRODUCTION: New research guidelines for the diagnosis of Alzheimer's disease (AD) include biomarker evidence of amyloid-β (Aβ) and tau pathology. The aim of this study was to investigate what proportion of AD patients diagnosed in clinical routine in Sweden that had an AD-indicative cerebrospinal fluid (CSF) biomarker profile.

METHODS: By cross-referencing a laboratory database with the Swedish Dementia Registry (SveDem), 2357 patients with data on CSF Aβ and tau biomarkers and a clinical diagnosis of AD with dementia were acquired.

RESULTS: Altogether, 77.2% had pathologic Aβ42 and total tau or phosphorylated tau in CSF. These results were stable across age groups. Female sex and low mini-mental state examination score increased the likelihood of pathologic biomarkers.

CONCLUSION: About a quarter of clinically diagnosed AD patients did not have an AD-indicative CSF biomarker profile. This discrepancy may partly reflect incorrect (false positive) clinical diagnosis or a lack in sensitivity of the biomarker assays.

Place, publisher, year, edition, pages
2015. Vol. 11, no 12, 1470-1479 p.
National Category
URN: urn:nbn:se:uu:diva-268015DOI: 10.1016/j.jalz.2015.04.007ISI: 000366721600008PubMedID: 26079415OAI: oai:DiVA.org:uu-268015DiVA: diva2:875452
Available from: 2015-12-01 Created: 2015-12-01 Last updated: 2016-03-21Bibliographically approved

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Kilander, Lena
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