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How to use D-dimer in acute cardiovascular care
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
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2017 (English)In: European heart journal. Acute cardiovascular care., ISSN 2048-8726, Vol. 6, no 1, 69-80 p.Article in journal (Refereed) Published
Abstract [en]

D-dimer testing is important to aid in the exclusion of venous thromboembolic events (VTEs), including deep venous thrombosis and pulmonary embolism, and it may be used to evaluate suspected aortic dissection. D-dimer is produced upon activation of the coagulation system with the generation and subsequent degradation of cross-linked fibrin by plasmin. Many different assays for D-dimer testing are currently used in routine care. However, these tests are neither standardized nor harmonized. Consequently, only clinically validated assays and assay specific decision limits should be used for routine testing. For the exclusion of pulmonary embolism/deep vein thrombosis, age-adjusted cut-offs are recommend. Clinicians must be aware of the validated use of their hospital's D-dimer assay to avoid inappropriate use of this biomarker in routine care.

Place, publisher, year, edition, pages
2017. Vol. 6, no 1, 69-80 p.
Keyword [en]
D-dimer, acute cardiovascular care, pulmonary embolism, thrombosis
National Category
Cardiac and Cardiovascular Systems
Identifiers
URN: urn:nbn:se:uu:diva-265866DOI: 10.1177/2048872615610870ISI: 000394780400007PubMedID: 26450781OAI: oai:DiVA.org:uu-265866DiVA: diva2:876733
Available from: 2015-12-04 Created: 2015-11-03 Last updated: 2017-04-25Bibliographically approved

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Christersson, ChristinaSiegbahn, AgnetaLindahl, Bertil

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