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Population genetic differentiation of height and body mass index across Europe
Univ Queensland, Queensland Brain Inst, Brisbane, Qld, Australia..
Univ Queensland, Queensland Brain Inst, Brisbane, Qld, Australia..
Erasmus Univ, Dept Internal Med, Med Ctr, Rotterdam, Netherlands..
Ist Ricovero & Cura Carattere Sci IRCCS, Inst Maternal & Child Hlth, Trieste, Italy.;Wellcome Trust Sanger Inst, Hinxton, Cambs, England..
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2015 (English)In: Nature Genetics, ISSN 1061-4036, E-ISSN 1546-1718, Vol. 47, no 11, 1357-1362 p.Article in journal (Refereed) Published
Abstract [en]

Across-nation differences in the mean values for complex traits are common(1-8), but the reasons for these differences are unknown. Here we find that many independent loci contribute to population genetic differences in height and body mass index (BMI) in 9,416 individuals across 14 European countries. Using discovery data on over 250,000 individuals and unbiased effect size estimates from 17,500 sibling pairs, we estimate that 24% (95% credible interval (CI) = 9%, 41%) and 8% (95% CI = 4%, 16%) of the captured additive genetic variance for height and BMI, respectively, reflect population genetic differences. Population genetic divergence differed significantly from that in a null model (height, P < 3.94 x 10(-8); BMI, P < 5.95 x 10(-4)), and we find an among-population genetic correlation for tall and slender individuals (r = -0.80, 95% CI = -0.95, -0.60), consistent with correlated selection for both phenotypes. Observed differences in height among populations reflected the predicted genetic means (r = 0.51; P < 0.001), but environmental differences across Europe masked genetic differentiation for BMI (P < 0.58).

Place, publisher, year, edition, pages
2015. Vol. 47, no 11, 1357-1362 p.
National Category
Medical Genetics
URN: urn:nbn:se:uu:diva-268419DOI: 10.1038/ng.3401ISI: 000363988200021PubMedID: 26366552OAI: oai:DiVA.org:uu-268419DiVA: diva2:877201
Swedish Research Council, M-2005-1112Swedish Foundation for Strategic Research EU, European Research Council, EU/QLRT-2001-01254EU, FP7, Seventh Framework Programme, FP7/2007-2013EU, European Research Council, 230374NIH (National Institute of Health), R01-D0042157-01ANIH (National Institute of Health), 1RC2-MH089951-01NIH (National Institute of Health), 1RC2-MH089995-01NIH (National Institute of Health), AA07535NIH (National Institute of Health), AA10248NIH (National Institute of Health), AA014041NIH (National Institute of Health), AA13320NIH (National Institute of Health), AA13321NIH (National Institute of Health), AA13326NIH (National Institute of Health), DA12854Wellcome trust
Available from: 2015-12-06 Created: 2015-12-04 Last updated: 2015-12-06Bibliographically approved

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